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The purpose of this study was to design a virtual reality curriculum model in science course based on a synthesis method. The statistical population of this study consisted of all valid scientific articles in the field of virtual reality that based on regular search of databases, 920 scientific articles were identified according to the inclusion criteria and finally 197 exclusion criteria were selected for final analysis. Were. A researcher-designed worksheet form was used to collect, report and record the initial research data. Findings were analyzed using Marshchr('39')s (1991) seven-step model of open synthesis and axial coding methods. Research findings show that the Virtual Reality-Based Curriculum in Science is a student-centered curriculum that creates different roles and responsibilities for the learner, teacher, and knowledge.