This study aims to investigate the relationship between wisdom and psychological well-being and academic buoyancy of students. This is a correlation study. The statistical population of this research includes all high school Secondary students of Khusf town, and 317 students were selected through cluster random sampling method. Research tools employed include Wisdom Scale of Ardelt, psychological well-being scale of Ryff and academic buoyancy of Dehqanizadeh and Hussein Chari. For analysis, Pearson correlation coefficient and regression analysis were adopted. Results showed that significant and positive relationship between wisdom and academic buoyancy and psychological well-being exist. The reflective and emotional components of wisdom predicted the level of psychological well-being, and cognitive and reflective components predicted the level of academic buoyancy. Thus, it can be concluded that wisdom is a reliable anticipator for academic buoyancy and psychological well-being between students, and wiser students have higher levels of academic buoyancy and psychological well-being.