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Based on the notions and assumptions of the discourse of “new urban regionalism”, there is a close relationship between the "spatial morphological structure" and the "spatial division of labor" in a megalopolis region, and solving existing problems in one without another is not possible, because they can either act in the direction of positive reinforcement and support, or in order to weaken and become an obstacle to each other; therefore, what is meant by the problem of achieving equilibrium and integration in the spatial structure and the functional system in a megalopolis region, will not be possible without recognizing the nature and relationship between these two. The reviews done the research shows that "spatial morphological structure" and "spatial division of labor" in Tehran's megalopolis region during the recent decades has not been able to support each other and significantly reduce the spatial non-equilibrium in the region. Therefore, according to the results obtained in the framework of this study, the "spatial morphological structure" and "spatial division of labor" in Tehran's megalopolis region during the recent decades (1345-1390), has been accompanied by a significant reduction in the spatial non-equilibrium in the region, though, the trend of transformations is on the move. One of the strategic implications of this is that the future issue of the Tehran's megalopolis region is to be more focused on the peripheral population poles and the improvement of the level of performance of the city itself in order to accept transnational functions and create alternatives and opportunities for roles and the tasks that will be assigned to them in the future. Just as in the prior years the industry sector has gradually shifted to the service sector, in the future it also seems necessary to give up the services sector to itself periphery and oppose the acceptance of the fourth sector of the global economy (such as; Information, communication and cultural economy).

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Landuse planning goals as the main core of urban planning are classified and studied from different aspects. The inclusion of additional value of surplus funds in the city can highlight capital funding. Following this, changes in urban land demand as the spatial changes of activities and functions occur.The commercialization of residential areas and the tendency of residential landuse changes are the disadvantages of these changes,which constitute a major part of residential neighborhoods of Tehran metropolis ,especially the northern neighborhoods of the city. The main structure of Nasr neighborhood in the 2th district of Tehran is based on Gisha street. The most important issue is multiplicity of commercial land uses in the Gisha street. According to the observations there is a bank in every 45metres of the street , while the performance radius of bank activities is defined in the region scale. It is argued that land price growth, financial and speculative justifications of these changes can cause pressure on the environment.Therefore, according to the above mentioned factors,the main objective of this study is identifing the factors affecting landuse changes in the Gisha street.
The research method in this study is documentary , local survey as well as the use of factor analysis in order to determine factors affecting landuse changes.By using this method, accessibility,landeconomics and activity distribution and neighborhood structure were considered as three factors affecting land use changes in the Gisha street .
Finally, in order to plan to control the speculative consequences of these changes , the analysis of external and internal factors with regard to indicators in questionnaire, SWOT table and finally defensive strategy to offer strategies and policies was adopted these strategies were presented in two categories: sustainable management of income sources of urban management and control of changes in land use changes.