Maternal alcohol abuse causes abnormal fetal development, a condition called fetal alcohol syndrome (FAS). Hydrocephalus is one of the main features accompanying this condition. The early sign of hydrocephalus in the fetal period is ventricolumegaly, followed by reduction in the cortex thickness. In this research hydrocephaly and its effect during ethanol exposure was investigated .To inducing FAS, pregnant Wistar rats were fed with 5) % w/v (liquid alcoholic diet from day 8 of pregnancy to delivery. Embryos of E18 and E19 days were decapitated and brains were removed and sectioned and stained by H&E and immunohistochemistry. The analysis of the brain sections revealed significant decrease (p

Keywords: Hydrocephalus, Fetal Alcohol Syndrome, Aquaporin1 (AQP1)

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