RT - Journal Article T1 - Teratogenic effects of Tolualdoxime on the Spermatogenesis of mature Balb/C mice JF - jsci YR - 2009 JO - jsci VO - 8 IS - 1 UR - http://jsci.khu.ac.ir/article-1-1221-en.html SP - 21 EP - 30 K1 - tolualdoxime K1 - teratogenic effects K1 - Spermatogenesis K1 - Balb C mice AB - Oxime is an important functional group in organic chemistry which can protect carboxilic groups and are applied as insecticides, fungicide and acaricides. It has been reported that some members of oxime family decrease spermatogenesis and oogenesis. Due to the similar structure of tolualdoxime with other oximes, in this study we evaluated the effects of tolualdoxime on spermatogenesis in order to achieve a male contraceptive compound with minimum side effects. LD50 standard was found 350 mg/kg B.W. In this research mature mice received 175 mg/kg /B.W. a daily single dose for two weeks .The analysis of results showed significant decrease in different parameters (p LA eng UL http://jsci.khu.ac.ir/article-1-1221-en.html M3 ER -