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Kharazmi University , vahid7fazeli@yahoo.com
Abstract:   (1187 Views)
Objective: The aim of the present study was to investigate the effect of combined exercise on aortic atherosclerosis and FGF23 in male rats with chronic Kidney disease (CKD). 
Methods: In this study, 20 male Wistar rats (mean weight 10 ± 250  g) were induced by NX5 / 6 method for chronic renal failure. After 2 weeks of recovery, they were randomly divided into two groups of control (n= 10) and combined training (n= 10) and performed a combined training protocol for 8 weeks. The combined training protocol consisted of two resistance training exercises on a ladder with 2 sets and 6 repetitions with percentages of body weight and aerobic exercise included 30 minutes of low-intensity treadmill activity. Data were analyzed using t-test. P < 0.05 was considered significant. 
Results: The results showed that combined exercise reduced aortic atherosclerosis and decreased plaques, and FGF23 decreased significantly (p = 0.001). Parathoromon hormone also significantly decreased (p = 0.041) and calcium and phosphorus significantly decreased (p = 0.004 and p = 0.005, respectively). 
Conclusion: Overall, the results showed that combined training could decrease FGF23, parathoromon hormone, calcium and phosphor on aortic atherosclerosis and cardiovascular disease indices in chronic Kidney disease (CKD) patients.
     
Type of Study: Research | Subject: Special
Received: 2019/10/27 | Accepted: 2019/11/1

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