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Showing 4 results for Khaledi

Mr Vahid Fazeli, Dr Pezhman Motamedi, Dr Hamid Rajabi, Dr Neda Khaledi,
Volume 0, Issue 0 (11-2019)

Objective: The aim of the present study was to investigate the effect of combined exercise on aortic atherosclerosis and FGF23 in male rats with chronic Kidney disease (CKD). 
Methods: In this study, 20 male Wistar rats (mean weight 10 ± 250  g) were induced by NX5 / 6 method for chronic renal failure. After 2 weeks of recovery, they were randomly divided into two groups of control (n= 10) and combined training (n= 10) and performed a combined training protocol for 8 weeks. The combined training protocol consisted of two resistance training exercises on a ladder with 2 sets and 6 repetitions with percentages of body weight and aerobic exercise included 30 minutes of low-intensity treadmill activity. Data were analyzed using t-test. P < 0.05 was considered significant. 
Results: The results showed that combined exercise reduced aortic atherosclerosis and decreased plaques, and FGF23 decreased significantly (p = 0.001). Parathoromon hormone also significantly decreased (p = 0.041) and calcium and phosphorus significantly decreased (p = 0.004 and p = 0.005, respectively). 
Conclusion: Overall, the results showed that combined training could decrease FGF23, parathoromon hormone, calcium and phosphor on aortic atherosclerosis and cardiovascular disease indices in chronic Kidney disease (CKD) patients.

E Fasihi Ramandi, N Khaledi,
Volume 18, Issue 19 (7-2020)

Diabetes is a common metabolic disease. In diabetic patients glucose uptake is reduced and FGF-21 plays an important role in glucose uptake, alsoTNF-α is an inflammatory factor that increases in diabetes. The purpose of this study was to investigate the effect of 6 weeks of HIIT training on the gene expression FGF-21 in the liver and the serum TNF-α level of male diabetic rats. For this purpose, 48 Wistar rats were randomly divided into four groups Control, diabetes, high intensity interval training, and diabetes and high intensity interval training. For the induction of diabetes, peritoneal injection (Streptozotocin 50 mg/kg) was used. Training protocol including 10 set of 1-minute running (between each set of 2 minutes of rest) 3 sessions per week and was completed within 6 weeks. Finally, after the extraction of liver samples, the expression of the FGF-21 gene was measured by Real Time PCR and serum TNF-α level with ELISA kit.There was no significant change in expression of FGF-21 in any group, but the reduction of serum levels of inflammatory factors, such as TNF-α protein at the level of significance (p=0.05), and maintaining and improving the time to exhaustion, was shown by high intensity interval training (0.000).Likely the inflammatory factors of diabetes such as TNF-α have a deleterious effect on the expression and binding of FGF-21 (β-Klotho) cofactors And causes resistance to FGF-21 into various tissues of the body, such as the liver. Exercise can reduce inflammation caused by diabetes.

Mohammad Azimnezhad, Pezhman Motamedi, Mohammadreza Dehkhoda, Neda Khaledi,
Volume 20, Issue 23 (9-2022)

Apoptosis is a programmed cell death and it’s associated with type 2 diabetes. The aim of present study was to investigate the effect of endurance training on caspase-3, Bcl-2 and Bax gene expression of cardiac tissue in type 2 diabetic male wistar rats.In an experimental trial, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (n=12), Diabetic Control (n=12) and Healthy Control (n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 20-30min in 1st week and reached to 27 m/min for 60 min/day in 10th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of caspase-3, Bcl-2 and Bax were examined by Real time-PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0.05. The gene expression of caspase-3and Bax of diabetic control group showed significant increase comparing with healthy control group (p =0.001) while gene expression of Bcl-2 significantly decreased (p =0.001). The endurance training induced significant reduction in the gene expression of caspase-3and Bax (p =0.001) and significant increase in the Bcl-2 compared to diabetic control group (p =0.001). It appears that gene expression of caspase-3, Bcl-2 and Bax of diabetic cardiac tissue are affected by positive effect of endurance training and the endurance training induces improvement in apoptosis of diabetic cardiac tissue.

Setare Beyhaghi, Neda Khaledi, Doctor Hossein Askari,
Volume 20, Issue 23 (9-2022)

Recent studies indicate that environment can modify skeletal muscle gene expression and transcriptional factors in offspring genes. Therefore, exercising can lead to changes in the gene expression of the future generations. One of the important metabolic factors is PDK4, which is known as the main factor in Pyruvate Dehydrogenase Complex (PDC). This study examined the effects of maternal exercise on PDK4 expression in slow and fast twitch (soleus and EDL) muscles of male offspring. Twenty Sprague-Dawley rats were divided to three training groups: before pregnancy (TBP), during pregnancy (TDP) and before and during pregnancy (TBDP) and pregnancy without training (control) group. Training groups were running on a treadmill for four, three and seven weeks, respectively. Two months after the birth of the offspring, 6 male rats were chosen randomly from the offspring of each group. The samples were anesthetized using Ketamine (90 mg/kg) and Xylazine (10 mg/kg) and their soleus and EDL muscles were removed immediately for examine. Gene expression of offspring muscles were analyzed using real-time RT-PCR. Fisher test were used to analyze the difference between the training and the control group. PDK4 expression of offspring were significantly increased in all groups except for EDL muscle of the TBP group. According to the results, it seems likely maternal exercise training can affect the metabolic regulation in the offspring by increasing the expression of some metabolic genes.

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