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Mr , Dr , Dr , Dr Mohammad Hassaan Dashty Khavidaki,
Volume 0, Issue 0 (11-2019)
Abstract


Abstract
Purpose:The aim of this study was to effect of quercetin exercise and supplementation on myostatin and folistatin levels in the heart tissue of diabetic rats.Methods:For this purpose, 50 male Wistar rats with an average weight of 237 33 33 g were randomly divided into five groups of 10 including: healthy control, diabetes, diabetes + supplement, diabetes + exercise and diabetes + supplement + exercise.The training week was five sessions per week and 60 minutes per session, and the supplement groups received 50 mg / kg body weight of quercetin daily by gavage. Located.Results:The results showed that there was a significant difference in myostatin levels between exercise + supplement and diabetes groups(P = 0.004) and myostatin levels between exercise + supplement + diabetes and diabetes groups were also significantly different (P = 0.002).There was a significant difference between the supplement + diabetes group compared to the diabetes and control groups(P = 0.001).There was also a significant difference between the supplement + diabetes and exercise + diabetes groups (P = 0.009). Rat heart tissue was observed in exercise + supplement + diabetes group compared to diabetes, control and exercise + diabetes groups(P = 0.001).Conclusion:It seems that the decrease in myocardial myostatin along with the increase in fulostatin, in addition to better showing the opposite role of these two important cardiac cardiacs in diabetic patients, also explains the importance of exercise and quercetin consumption in this disease.
 
E Fasihi Ramandi, N Khaledi,
Volume 18, Issue 19 (7-2020)
Abstract

Diabetes is a common metabolic disease. In diabetic patients glucose uptake is reduced and FGF-21 plays an important role in glucose uptake, alsoTNF-α is an inflammatory factor that increases in diabetes. The purpose of this study was to investigate the effect of 6 weeks of HIIT training on the gene expression FGF-21 in the liver and the serum TNF-α level of male diabetic rats. For this purpose, 48 Wistar rats were randomly divided into four groups Control, diabetes, high intensity interval training, and diabetes and high intensity interval training. For the induction of diabetes, peritoneal injection (Streptozotocin 50 mg/kg) was used. Training protocol including 10 set of 1-minute running (between each set of 2 minutes of rest) 3 sessions per week and was completed within 6 weeks. Finally, after the extraction of liver samples, the expression of the FGF-21 gene was measured by Real Time PCR and serum TNF-α level with ELISA kit.There was no significant change in expression of FGF-21 in any group, but the reduction of serum levels of inflammatory factors, such as TNF-α protein at the level of significance (p=0.05), and maintaining and improving the time to exhaustion, was shown by high intensity interval training (0.000).Likely the inflammatory factors of diabetes such as TNF-α have a deleterious effect on the expression and binding of FGF-21 (β-Klotho) cofactors And causes resistance to FGF-21 into various tissues of the body, such as the liver. Exercise can reduce inflammation caused by diabetes.
 

Dr Ali Asghar Ravasi, Dr Mousa Khalafi, Dr Karim Azali Alamdari,
Volume 19, Issue 22 (12-2021)
Abstract

Background and objective: Effects of exercise training on metabolic disorders through modifications in fibroblast growth factor -21 (FGF-21) level are controversial. Therefore, the aim of study was to determine the quantitative effect of exercise training protocols on serum FGF-21 level in adults with metabolic disorders. Methods: A systematic search of the published Persian or English-language studies from PubMed and Google Scholar databases up to march 2021 was done and standardized mean differences (SMDs) were calculated using random-effects models. Results: a total of 14 studies (aerobic training=3, resistance training=3, HIIT=4, concurrent training=4) including on 19 interventions conducted on 503 subjects (with overweight, obesity, type 2 diabetes, metabolic syndrome and or fatty liver disease) were eligible to include in the meta-analysis. However, because of the heterogeneity, the final quantitative impact of 16 interventions was calculated as a declining serum FGF21 level after training [SMD=-0.44(CI: -0.65 to -0.22) p=0.001] which had no correlation with subjects age(p=0.10) or BMI(p=0.50) level. Conclusion: exercise training protocols are efficient tools for a remarkable decrease in serum FGF-21 in patients with metabolic disorders which seems to lead to more beneficial effects on metabolic disturbances. However, more clinical trials are still warranted in this area considering the role of exercise components such as exercise intensity and type


Dr Ali Barzegari, Dr Saeid Naghibi, Samaneh Safayi, Dr Mohammadhasan Dashti Khovidaki, Dr Anahita Salehi,
Volume 20, Issue 24 (3-2023)
Abstract

The purpose of this study was to compare two methods of aerobic exercise on the levels of SOD and TNF-α in the heart tissue of diabetic rats. 40 male Wistar rats aged ten weeks were randomly divided into four groups of 10: healthy control, diabetes, diabetes+MIT and diabetes+HIT. The moderate intensity training group ran 5 sessions per week for 8 weeks on the treadmill for 60 minutes at a speed of 25 meters per minute, and the high intensity training group also 5 sessions per week for 8 weeks with a training time of 60 minutes and at a speed of 34 meters per minute. The heart tissue of rats was examined to determine the amount of changes in SOD and TNF-α using ELISA method. To investigate the difference between groups of variables, one-way analysis of variance and Tukey's post hoc statistical tests were used at the significance level of P≥0.05. The results showed that there was a significant difference in the levels of TNF-α and SOD in the heart tissue of rats among the four research groups (P≤0.001). The levels of TNF-α in the HIT training group also showed a significant decrease compared to the diabetic group (P=0.001), While these changes in the MIT exercise group compared to the diabetes group was a non-significant decrease (P=0.117), the amount of SOD levels between the MIT and HIT exercise groups also showed a significant increase compared to the diabetic group (P=0.001). It seems, aerobic exercise with different intensities can improve SOD and TNF-α levels. Although the intensity of exercise in periodic exercise has been an effective factor in changing the values of both variables.


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