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Ms Leila Gholami, Dr Farnoosh Attari, Dr Mahmood Talkhabi, Ms Fatemeh Saadatpour,
Volume 0, Issue 0 (6-2023)

Breast cancer is the most common cause of death from cancer among women. The triple-negative breast cancer (TNBC) is the most invasive subtype, and chemotherapy is the only therapy option. Cancer cells preferably utilize the glycolysis pathway even with proper oxygen availability, and this activation plays a great role in tumorigenesis. Therefore, glycolysis targeting can be an effective strategy for cancer treatment. Here, the apoptotic effect of a glycolysis inhibitor named dichloroacetate (DCA) on TNBC cells MDA-MB-231 was assessed, and the expression of anti-apoptotic genes and oncogenic miRNAs was evaluated. MTT assay showed that DCA reduces cell viability in a dose-dependent manner with the IC50 concentration of 50 mM. Annexin/PI assay demonstrated that DCA increased apoptosis rate up to 32%, and cell cycle analysis revealed the 2-time augmentation of the sub-G1 population due to DCA treatment. Finally, the expression of anti-apoptotic genes Bcl2l1 and Mcl1 and oncogenic miRNAs miR21 and miR27a decreased due to DCA treatment. Our results confirmed that DCA as a glycolysis inhibitor leads to apoptosis induction in TNBC cells because of reducing expression of viability genes and miRNAs.  
Maryam Keshavarzi, Akram Gholami , Zahra Nazem Bokaee,
Volume 3, Issue 4 (3-2017)

With 29 species in Iran, Polygonum L. is comprised of annual and perennial plants in different habitats. P. aviculare makes a species complex, hardly distinguished from P. arenastrum and P. patulum. In the present study, po-llen grains, fruit surface and petals and leaves epidermis features were used to provide diagnostic features in order to se-parate species from one another. In Total, 33 populations of 6 annual species, including P. aviculare, P. arenastrum, P. patulum, P. argyrocoleon, P. polycnemoides and P. olivascens were studied. Specimens were gathered during field trips and studied by means of light and scanning electron microscopes. The Pollen grains of all the species which were stud-ied were monad, subprolate or prolate spheroidal and tricolpate. Main differences were also observed in their surface ornamentations. Length of equatorial and polar axes and colpus, granules diameters and the average distance between granules were other diagnostic features of the pollen grains. Statistical analysis of epidermis features revealed that the length and width of epidermis cells and stomata length varied in the species studied. A close relationship was found between P. aviculare and P. arenastrum on the one hand and P. argyrocoleon and P. olivascens on the other. The sepa-ration of P. polycnemoides could be attributed to differences in epidermis features. Results showed that a selected set of these features to be of taxonomic importance.

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