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Showing 3 results for Soltani

Sasan Ghobadian, Hossein Ganjidoust, Bita Ayati, Neda Soltani,
Volume 5, Issue 1 (6-2018)

Special properties and various applications of Spirulina species have led to the growing focus of biotechnology to the cost effective cultivation. Open ponds used in the most commercial cultivation have many deficiencies such as risk of contamination, lack of light penetration, inefficient mixing and low productivity. In this study, an innovative reactor was designed and manufactured. By adding a control area, it was possible to control some environmental conditions for a limited amount of open pond volume. The conventional pumping system was replaced by a new elevator system to reduce the damage of to the fragile cells. The baffles structure and aeration from bottom, contributed to better mixing system. The effect of tree factors (Circulation Cycle (Cir. Cyc.), Control Volume (Con.Vol.) and Irradiance Intensity (Irr. Int.) in units of hours, percentage and Lux respectively) on the quantity of biomass (Specific Growth Rate (SGR, day-1) and fifth and seventh day dry weight (g/L)) were evaluated using RSM-CCD. The maximum biomass dry weight (0.915 g/L) was achieved in longest circulation cycle (12 hours), 30% Con. Vol. and 7000 Lux light intensity. The optimal irradiance intensity to achieve the highest biomass was 8700 Lux. According to the results, due to the great influence of Con. Vol. and Cir. Cyc., it is possible to increase the productivity and enhance the culture dry weight by controlling a limited amount of ponds volume (20%), subject to economic considerations. These successful results can provide the context using a control zone for several open ponds to improve the overall efficiency.

Seyed Mousa Mousavi Kouhi, Maryam Moudi, Esmael Soltani Moghadam, Hedyieh Sarchahi Moghadam,
Volume 6, Issue 1 (5-2019)

The identification of the characteristics of native halophytic species is very important for their practical application. The present study was carried out to identify the halophytic species of a desert and highly saline region around the city of Khosf, southern Khorasan Province, and to detect their general tolerance mechanisms (i.e. salt exclusion or inclusion). Sodium accumulation in the roots and shoots of seven species, including Launaea arborescens, Peganum harmala, Pteropyrum olivieri, Artemisia santolina, Zygophyllum eurypterum Boiss, Aerva javanica, Pulicaria gnaphalode, and their rhizosphere soil were determined. The bioconcentration of sodium from soil to roots (BCF), its translocation from roots to shoots (TF), and its accumulation in the shoots (AF) were then calculated. Results showed that the soil of the studied area was clay loam with a high EC of 65 ds/m, indicating its high salinity level. According to the values of sodium adsorption ratio (SAR) and the exchangeable sodium percentage (ESP) and regarding EC, the soil of studied region can be regarded as a saline-sodic soil. The value of TF in some species was higher than 1. However, none of the species had BCF and AF greater than 1, thus, none of them could be considered to be salt accumulator. Instead, it could be assumed that all of the studied species were salt, or at least, sodium excluders.
Golnaz Parvizi Fard, Lale Solouki, Mostafa Zakariazadeh, Hossein Haghaei, Somaieh Soltani,
Volume 9, Issue 3 (12-2022)

Human serum albumin is one of the most important blood proteins that has the ability to bind a wide range of compounds and different drugs. Hence, knowing how drugs bind to albumin is crucial to understand their pharmacokinetics and pharmacodynamic properties. The binding of drugs to protein affects the drug's excretion, distribution and interaction in the target tissues. Nicotinamide (NA) is a safe and inexpensive medical supplement that used to prevent and treat vitamin B3 deficiency. In this research, the molecular mechanism of the interaction between nicotinamide and human serum albumin was studied by the utilization of spectroscopic and molecular docking methods. The effects of temperature, acidic/basic pHs, metal ions, urea, and glucose on the interaction between nicotinamide and human serum albumin were also investigated. The spectroscopic studies indicated that the interaction between nicotinamide and human serum albumin is mainly controled by hydrophobic forces and the interaction is spontaneous. The number of binding site and binding constant is 1 and 4.6×104 (L/mol), respectively, which were increased in the presence of glucose. The presence of metallic ions and basic pH decreased the binding constant of nicotinamide to albumin. The obtained results indicated that nicotinamide tend to binds to the similar sites wherever the molecules with acidic moieties bind. The results could be helpful to interpret the mechanisms of actions of nicotinamide in the various physiological phenomena in the human body.

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