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Elahe Samani Jahromi, Madjed Rezai-Zadeh, Samaneh Zolghadri Jahromi,
Volume 3, Issue 4 (3-2017)

The study attempts to evaluate the effects of silver nanoparticles on preventing the destruction of ovarian tissue in mice treated with isoniazid. In this experiment, 40 adult female rats were randomly divided into 5 groups (n=8) including: control group (no treatment), sham group (0.2 mg / kg normal saline), experimental group 1 (50mg / kg Ison-iazid), experimental group 2 (50mg / kg Isoniazid and 0.25mg/kg silver nanoparticles) and the experimental group 3 (50mg / kg isoniazid and 0.50mg / kg silver nanoparticles). All injections were prescribed for 15 days and Isoniazid and silver nano-particles were received orally and intraperitoneally, respectively. All the animals were operated on and their ovarian tissues were removed and placed in 10% formalin solution. Then H & E staining was performed for histological studies. In experimental groups 1, 2 and 3, reduction in the number of secondary follicles and corpus luteum was obse-rved in comparison with the control group. There was a significant increase in the number of primordial and graafian follicles in experimental group 3 when it was compared with isoniazid group. In addition, a significant increase was observed in the number of primary monolayer follicles in experimental groups 2 and 3 in comparison with the experi-mental group 1. It should be assumed that by the utilization of the minimum dose of the silver nanoparticles, its toxic effects on the ovarian tissue could be ignored. Therefore, the minimum dose of the silver nanoparticles can reduce the isoniazid effects on ovarian tissue.

Seyed Mohammad Ali Shariatzadeh, Mrs. Zahra Alizadeh,
Volume 9, Issue 2 (9-2022)

Seyed Mohammad Ali Shariatzadeh & Zahra Alizadeh
Department of Biology, Faculty of Sciences, Arak University, Arak, Iran
Correspondent author: Seyed Mohammad Ali Shariatzadeh,

Abstract. Silver nanoparticles (Ag NPs) can affect female fertility because they can cause toxicity in the ovaries. The aim of this study is to see if Spirulina platensis (SP) can protect mouse from Ag NPs-exposed toxicity in its ovary. Twenty-four female Naval Medical Research Institute (NMRI) mice were divided into four groups (n = 6 per group): control; Ag NPs (500 mg/kg daily); SP (300 mg/kg daily) and Ag NPs + SP (With the same defined doses). 30 days after oral gavage treatment, biochemical parameters were measured and ovary compartments were estimated stereologically. The Ferric Reducing Antioxidant Power (FRAP) values, hormonal concentrations, corpus luteum volume, and the number of healthy follicles were all significantly lower (p<0.05) in the Ag NPs group compared with the control group. in the SP group, malondialdehyde concentration and atretic follicles were significantly lower (p<0.05) compared with the control group. There was no significant difference in the mean total volume of ovary, cortex, medulla, oocyte and its nucleus, and the thickness of the zona pellucida in any group. Although, SP in the Ag NPs + SP group cannot compensate the above parameters to the control level, it considerably improves ovarian damage caused by Ag NPs through reducing oxidative stress.

Key words. follicles, hormones, oxidative stress, stereology, zona pellucida

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