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Azar Beikazade, Mohammadreza Imanpour, Vahid Taghizade,
Volume 2, Issue 2 (9-2015)

Cortisol is a corticosteroid hormon which has important effects on osmoregulation in marine fish. In this study the effect of oral cortisol on resistance (salinity stress in 12ppt during 7 days) in common carp (cyprinus carpio) fry was investigated. For this purpose, common carp (1.36±0.12 gr) was distributed in 3 treatments and 1 control group in 3 replicates and fed with commercial food containing 0 (control), 50, 100 and 200 mg kg-1 food hydrocortisone during 8 weeks. At the end of the trial, hematocrit, biochemical blood parameters (glucose, calcium and total protein) and resistance of fish were determined. The results showed no significance in survival rates between treatments (p>0.05). Glucose levels in the control treatment was significantly lower than other treatments at the end of the trail by serological investigation (p<0.05). Fish were let in salinity stress and after 7 days all treatments showed a significant increase in the value of glucose (p<0.05). The highest value of glucose was observed in fish on fed 100 and 200mg hydrocortisone per kg-1 food )73.04±1.40) (p<0.05) and the highest level of haematocrit was observed after stress in the control group (61.67±2.08) (p<0.05). Calcium Ionic factor showed a significant increase in all treatments except for the control treatment (11.17±0.31) (p<0.05) and the highest value was observed in fish fed 200 mg hydrocortisone per kg-1. Total protein in fish treat-cortisol was significantly lower than the control group (p<0.05). The results of this study showed that oral administration of cortisol can improve the salinity resistance in the common carp fry

Zahra Roohi, Mohammad Reza Imanpoor, Valiolah Jafari , Vahid Taghizadeh,
Volume 4, Issue 1 (6-2017)

This study was conducted in order to measure glucose, cholesterol and hematocrit as indicators to evaluate the effect of caraway seeds meal (CSM) on the health and resistance of common carp to salinity stress. To attain this goal, fish (2.457±0.057 g) were divided into four groups fed on diets containing different levels of CSM; 0 (control), 0.5, 1 and 1.5%. After 56 days of feeding, blood samples of the fish were obtained in five stages (once before and four times after stress) to evaluate glucose, cholesterol and hematocrit levels. The experiments indicated that salinity sign-ificantly affected glucose, cholesterol and hematocrit. On the first day after stress, the hematocrit and glucose levels were considerably increased in all groups compared with their levels before stress. After stress, cholesterol level signif-icantly decreased in all groups compared to before stress. The level of hematocrit indicated no significant difference among the groups before and after stress. On the first day after stress, the glucose levels significantly increased in trea-ted groups with CSM compared with the control group. The glucose and hematocrit levels were decreased gradually in all groups from the third day on. After stress, no differences were observed for survival rates among the experimental diets. However, the highest survival rate belonged to treated groups with CSM. The overall result indicated that the suplement of CSM has a positive influence on the glucose, hematocrit and resistance of common carp to salinity stress.

Babak Hassan Khan, Parichehreh Yaghmaei, Kazem Parivar, Azadeh Ebrahim Habibi,
Volume 9, Issue 3 (12-2022)

Irisin is a myokine secreted mostly by muscles after exercise, and its secretion level changes in metabolic disorders. The aim of present study was to investigate the effect of metformin on changes in the levels of plasma irisin, blood glucose and insulin resistance in male Sprague-Dawley rats receiving a high-fat emulsion diet. Twenty-four rats were divided into a normal control group (n = 8) and a high-fat diet group (n = 16). Then, high-fat diet group was divided into two subgroups, including high-fat diet control group (n = 8) and metformin group (n = 8). The normal control group received a standard diet. The high-fat diet control group received a high-fat emulsion diet containing corn oil by gavage on a daily basis for six weeks, and the metformin group received a high-fat emulsion diet with metformin (250 mg/kg/daily). At the end of the six-week period, factors such as glucose, insulin, irisin, Adiponectin, insulin resistance, liver enzymes, tumor necrosis factor α (TNF-α), serum lipid profile, lipid profile and lipid peroxidation in liver were measured and PGC-1α gene expression were examined in adipose tissue by Real-time PCR method. Liver histological tests with hematoxylin-eosin staining were performed to evaluate fat accumulation in liver tissue. Blood glucose level, insulin resistance, adiponectin, serum irisin level and liver lipid profile in the group receiving high-fat diet compared to the normal control group increased significantly (P <0. 05). Treatment with metformin caused a significant decrease in the level of these parameters compared to the high-fat diet group (P <0. 05) and an increase in the expression of PGC-1α gene in adipose tissue was observed in this group. As insulin resistance increased in rats receiving the high-fat diet, serum irisin level also increased, and with improving blood glucose and insulin resistance by metformin, serum irisin level was decreased. These results suggested that the elevated irisin levels may be a compensatory response to insulin resistance and impaired glucose metabolism. Hence, irisin could be considered as a potential target for the treatment of type 2 diabetes.

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