Family cohesion and adaptability is an emotional bind among family members and ability to change of power structure and role relationships in marital life. This study aimed to examine the relationship of marital intimacy and spirituality with family cohesion and adaptability. In this descriptive correlation study 234 married men and women that consisted of students and employees from Shahrood and Mayamey  cities completed marital intimacy, spiritual experience and family cohesion and adaptability scales. Data analyzed with Pearson correlation coefficient and stepwise regression method using SPSS-16. Results showed that openness (marital intimacy subscale), and god related effect (spirituality subscale), rolled in prediction of family cohesion, as well, intimacy problems (marital intimacy subscale), and sociospritual activities (spiritual subscale), rolled in prediction of family adaptability. It seems that people with high spirituality that experience intimacy relationships in marital lives, reported high family cohesion and adaptability.