Background: fatigue is an unpleasant mental feeling that has also been shown to decrease physical and Mental performance. Fatigue is a very common complaint and it is important to Healthcare Experts. Aim: this study was aimed to compare the meta-cognition of people with cronic fatigue and healthy. Metods: In this study, 120 undergraduate students (60 cronic fatigue and 60 healthy) of Tabriz University were selected by multi-stage cluster sampling and screening metods. The participants filled Fatigue Impact Scale (FIS) and short form of Wells meta-cognition scale (MCQ-30). Analyzing data was performed via independent samples t test. Results: Research findings revealed no diffrences in subscales of cognitive self-consciousness and negative beliefs about thoughts concerning uncontrollability, but there were diffrences in positive beliefs about worry, lack of cognitive confidence and beliefs about the need to control thoughts, significantly. Conclusion: On the basis of results, focusing on the role of meta-cognition could be the important part of therapeutic interventions for the people with chronic fatigue syndrome.