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Electronic mail (e-mail) as a means of fast and effective communication which has removed the barriers of distance and time has become very commonplace and important in institutional environments. Speakers of English as a foreign language across different disciplines need to enhance their awareness of the generic and formal features of the e-mail genre in order to maximize the efficiency and effectiveness of their correspondence. Following genre analysis studies such as Swales (1990), Bhatia (1993), Santos (2002), Vergaro (2004), and Samraj and Monk (2008), and in line with studies on electronic messages such as  Gains (1999), Gimenez (2000, 2006), and Jensen (2009), the present genre-based research was conducted to analyse e-mails exchanged between EFL teachers and biology professionals for the purposes of requesting and providing information at two criteria of the macro-textual and micro-levels of the two corpora to present a tentative model. The results revealed clear discrepancies between the parallel constitutive moves, strategies and formal features due to cross-disciplinary variations and the prevalence of intertextuality. The findings of this study have pedagogical implications for devising courses, preparing teaching materials and raising ESP instructors' awareness of learners' problems.