Always new technologies exports have been regarded as a competitive advantage and it implies the dynamism and cohesion of the economy and its special position in the global markets. Lack of innovation is one of the main factors affecting the country's high-tech exports. And until innovation and training to use of knowledge do not improve, efficiency and effectiveness of other production factors will remain low. So, the aim of this paper is to evaluate the effect of innovation on high technology exports in selected developing and developed countries during the period 2007-2013, using panel data approach and simultaneous equations system. Estimates of general model in developing countries expresses that the coefficients of global innovation index, accumulation of FDI inflows and GDP is positive and significant and coefficient of governance index is positive and meaningless. And in developed countries, coefficients of global innovation index, accumulation of FDI inflows, GDP and governance index is positive and significant. Therefore, it is necessary to improve the innovative environment, by changing the policy making in the resource-based economy moving towards knowledge-based economy by the alignment of macro-economic policies with scientific and research policies, in order to strengthen the relationship between industry and academia. So based on the current needs, the productions and technologies of knowledge-based industries will change.