Volume 18, Issue 56 (No.1&2-صفحات انگلیسی از 141 تا 148 2006)
2006, 18(56): 497-504 |
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Isolation and Identification of Iovastatin -Producing Microorganism and Determination of Optimal Fermentation Conditions. Journal title 2006; 18 (56) :497-504
URL: http://jsci.khu.ac.ir/article-1-1173-en.html
URL: http://jsci.khu.ac.ir/article-1-1173-en.html
Abstract: (4774 Views)
From 28 Aspergillus terreus, three produced lovastatin with equivalent or better yield than strain ATCC 20542 originally described for lovastatin production. Medium optimization experiments with the best isolate (Gil- 4) indicated that lactose, soya meal and KNO3 were the best sources carbon, organic nitrogen and inorganic nitrogen sources, respectively. In shake-flasks with optimized medium containing 4 % (w/v) lactose, 400 g lovastatin/ml was produced, with a yield of 10 mg/g lactose. In solid substrate fermentation on extracted sweet sorghum pulp supplemented with cheese whey 1500 g lovastatin/g dry weight was produced with a yield of 37.5 mg/g lactose.
Published: 2006/09/15
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