دوره 17، شماره 18 - ( 10-1398 )
جلد 17 شماره 18 صفحات 11-1 |
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Kazem A, Haghpanah A, Dakhili A. The effect of high-intensity exercise training on gene expression of tweak and Fn14 in EDL muscle of aged and adult mice. RSMT 2019; 17 (18) :1-11
URL: http://jsmt.khu.ac.ir/article-1-395-fa.html
URL: http://jsmt.khu.ac.ir/article-1-395-fa.html
کاظمی عبدالرضا، حق‌پناه علیرضا، دخیلی امیربهادر. تأثیر چهار هفته تمرین HIIT بر بیان ژن Tweak و Fn14عضلۀ EDL موشهای پیر و بالغ. پژوهش در طب ورزشی و فناوری. 1398; 17 (18) :1-11
چکیده: (3943 مشاهده)
آتروفی عضلانی از پیامدهای سالمندی است و فعالیت ورزشی ممکن است از آن جلوگیری کند. هدف پژوهش حاضر بررسی اثر تمرین تناوبی شدید بر بیان ژنهای Tweak و Fn14 عضلۀ EDL موشهای پیرنژاد C57bl/6 است. به این منظور، 28 سر موش C57bl/6 پیر (14=n) 24 تا 26 ماه و بالغ (14=n) چهار تا شش ماه در دو گروه تمرین (7=n) و کنترل (7=n) قرار گرفت. گروههای تمرین پس از یکهفته آشناسازی، در برنامۀ چهار هفته‌ای تمرین تناوبی شدید روی تردمیل با شدت 85 درصد سرعت بیشینه در هفتۀ اول تا 95 درصد سرعت بیشینه در هفتۀ آخر، در تناوبهای دو دقیقهای (شش وهله در هفتۀ اول تا ده وهله در هفتۀ آخر) یا یک دقیقه استراحت غیرفعال، مشارکت داده شدند. 48 ساعت پس از آخرین جلسۀ تمرینی، عضلۀ EDL استخراج شد و میزان بیان ژنهای Tweak و Fn14 اندازه‌گیری شد. نتایج نشان داد که پیری اثر معنیداری بر وزن عضلۀ EDL دارد (0/032=P)؛ همچنین، پیری موجب افزایش معنیدار بیان Tweak و Fn14 شده است (به ترتیب 0/001=P و 0/002=P)؛ تمرین ورزشی بیان این ژنها را در عضلۀ EDL هر دو نوع موش بالغ و پیر کاهش داد (0/001=P)؛ از سوی دیگر، با اینکه تمرین ورزشی وزن عضله را مقداری افزایش داد اما این مقدار به‌لحاظ آماری در هر دو گروه بالغ (0/117=P) و پیر (0/321=P) معنیدار نبود؛ بنابراین، افزایش سن با افزایش بیان ژنهای Tweak و Fn14 همراه است که ممکن است به تغییرات تودۀ عضلانی همراه با افزایش سن مربوط باشد و با توجه به کاهش بیان این ژنها بر اثر تمرینات شدید، این تمرینات ممکن است در دوران سالمندی به منظور حفظ تودۀ عضلانی مؤثر باشد.
نوع مطالعه: پژوهشي |
دریافت: 1398/11/15 | پذیرش: 1398/11/15 | انتشار: 1398/11/15
دریافت: 1398/11/15 | پذیرش: 1398/11/15 | انتشار: 1398/11/15
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