The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NN

Mirdar Harijani, Sh; Musavi, N

doi:10.29252/jsmt.18.19.113

Volume 18, Issue 19 (7-2020) RSMT 2020, 18(19): 113-126 | Back to browse issues page

‎ 10.29252/jsmt.18.19.113

‎ 20.1001.1.22520708.1399.18.19.9.0

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Mirdar Harijani S, Musavi N. The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NN. RSMT 2020; 18 (19) :113-126
URL: http://jsmt.khu.ac.ir/article-1-438-en.html

The effect of 12 weeks of submaximal swimming training on immunoreactivity of Ras and Raf-1 in lung epithelial cells of Wistar rats exposed to carcinogen NN

Sh Mirdar Harijani

, N Musavi

, narciss.mousavi61@gmail.com

Abstract: (4690 Views)

The aim of this study was to investigate changes in immunoreactivity of Ras and Raf-1 in lung epithelial cells of rats exposed to carcinogen NNK after swimming training. 50 Wistar rats were randomly divided into five groups: control, training, training + NNK, NNK and sham. NNK-induced groups received NNK Subcutaneously once a week at a dose of 12/5 mg per kg body weight for 12 weeks. The exercise training consisted of submaximal swimming training for 12 weeks. The percentage of reaction of Ras and Raf-1 in lung epithelial cells were measured by HIC. It was observed no significant change in the Ras and Raf-1 immunoreactivity of lung epithelial cells in training group compared to control. A significant incretion of the Ras and Raf-1 immunoreactivity was found in NNK group compared to control group (p=0.001). Furthermore, a significant reduction of the Ras and Raf-1 immunoreactivity was observed in exercise + NNK group when compared to NNK group (p=0.001). Generally it could be confirmed that regular submaximal aerobic training plays an important role in inhibition of the effects of lung carcinoma induced by NNK via reduction of Ras and Raf-1 activity.

Keywords: Lung, Cancer, Cigarette Smoke, nAChRs, β-ARs

Full-Text [PDF 1418 kb] (971 Downloads)

Type of Study: Research |
Received: 2020/07/19 | Accepted: 2020/07/15 | Published: 2020/07/15

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