دوره 19، شماره 22 - ( 10-1400 )
جلد 19 شماره 22 صفحات 151-130 |
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Ravasi A A, Khalafi M, Azali Alamdari K. Effect of Exercise Training on Serum FGF21 Level in Adults with Metabolic Disorders, A Meta-Analysis. RSMT 2021; 19 (22) :130-151
URL: http://jsmt.khu.ac.ir/article-1-495-fa.html
URL: http://jsmt.khu.ac.ir/article-1-495-fa.html
رواسی علی اصغر، خلفی موسی، آزالی علمداری کریم. تأثیر تمرین ورزشی بر غلظت سرمی فاکتور رشد فیبروبلاستی 21(FGF-21) در بزرگ‌سالان دارای اختلالات متابولیکی: یک مطالعه فراتحلیلی. پژوهش در طب ورزشی و فناوری. 1400; 19 (22) :130-151
دانشگاه شهید مدنی آذربایجان ، k.azali@azaruniv.ac.ir
چکیده: (3108 مشاهده)
مقدمه و هدف. اثر تمرینات ورزشی بر نارسایی‌های متابولیک از طریق دست‌کاری عامل رشد فیبروبلاستی-21 (FGF-21) متناقض است. بنابراین، هدف تحقیق تعیین اثر کمّی تمرینات ورزشی بر FGF-21 سرم بزرگ‌سالان دارای اختلالات متابولیک بود. روش‌شناسی. ابتدا جستجوی پایگاه‌های اطلاعاتی PubMed و Google Scholar برای استخراج مقاله‌های فارسی و انگلیسی منتشره شده تا اردیبهشت 1400، انجام شد و اندازه اثر (SMD) با مدل اثرات تصادفی محاسبه شد. یافته¬ها: 14 مطالعه شامل 19 مداخله(شامل تمرین هوازی(3=n)، تمرین مقاومتی(3=n)، تمرین تناوبی شدید(4=n) و تمرین ترکیبی(4=n)) دربردارنده اطلاعات 503 آزمودنی(دارای اضافه‌وزن یا چاقی و یا مبتلا به دیابت دو، سندرم متابولیک و کبد چرب)، واجد شرایط ورود به فراتحلیل شدند. اما به دلیل وجود ناهمگونی، درنهایت اثر کمی 16 مداخله به صورت کاهش FGF21 سرم پس از تمرین[001/0p=، (22/-0 الی 65/0CI: -) 44/0-SMD=] به دست آمد که با سن(10/0=P) و شاخص توده بدن(50/0=P) آزمودنی‌ها همبستگی نداشت. بحث و نتیجه‌گیری: تمرینات بدنی بی‌اعتنا به سن یا وضعیت وزنی، ابزار کارآمدی برای کاهش قابل‌ملاحظه FGF21سرم بیماران متابولیک هستند که انتظار می‌رود به بهبود بیشتر اختلالات متابولیکی منجر شود. با این حال، هنوز هم نیاز به کارآزمایی‌های بالینی بیشتر با در نظر گرفتن نقش مؤلفه‌های تمرینی از جمله شدت و نوع تمرین در این زمینه باقی است.
واژه‌های کلیدی: پسران چاق، آدیپونکتین، تمرین تناوبی شدید، آنزیم‌های آسپارتات آمینوترانسفراز، آلکالین فسفاتاز، آلانین آمینو ترانسفراز ترانسفراز
نوع مطالعه: كاربردي |
موضوع مقاله:
فیزیولوژی ورزشی
دریافت: 1400/3/30 | پذیرش: 1400/8/27 | انتشار: 1400/10/1
دریافت: 1400/3/30 | پذیرش: 1400/8/27 | انتشار: 1400/10/1
فهرست منابع
1. رفرنس های متنی مثل خروجی کراس رف را در اینجا وارد کرده و تایید کنید
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