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Introduction and purpose:Alzheimer's disease is one of the most common diseases of brain cell degeneration, one of its symptoms is depression.The aim of this study was the effect of a course of exercise training on the level of depression and oxidative stress factor changes in the hippocampus and prefrontal cortex of rats with Alzheimer's disease.
Methodology:For this purpose,40 8-week-old male Wistar rats with an average weight of237±33grams were randomly divided into four groups of 10: control,exercise,Alzheimer's,and exercise+Alzheimer's.The exercise protocol included 2 weeks of running on a treadmill at a speed of12 m/min and for 30minutes in each session. At the end of the training period, feeding sensation suppression and tail suspension tests were performed to estimate depression as well as hippocampal and prefrontal malondialdehyde levels using the Bradford method.
Results:The results showed that exercise training significantly reduced the rate of depression in Novelty-suppressed feeding test and suspension test in rats with Alzheimer's disease.Also,exercise training significantly reduced malondialdehyde levels in the hippocampus of rats with Alzheimer's disease while no significant difference was observed in the prefrontal.
Discussion It seems that sports activity can create immunity against Alzheimer's disease and is probably effective in preventing the occurrence of depression in Alzheimer's patients.
Type of Study: Research | Subject: sport physiology
Received: 2022/06/21 | Accepted: 2023/06/7

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