Showing 5 results for Azali Alamdari
Ssaeedeh Shiri Lord, Roghayeh Fakhrpour, Karim Azali Alamdari,
Volume 0, Issue 0 (11-2019)
Abstract
Background and Purpose; Sarcopenia is a progressive and generalized skeletal muscle disorder that involves rapid loss of muscle mass and function. The purpose of this study was to investigate the effect of continuous aerobic exercise on sarcopenia, changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's disease, to investigate the effect of physical activity on reducing sarcopenia and changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's should be measured.
Materials and Methods; In the present study, 40 aged Wistar rats with an average weight of 300 grams. The rats were randomly divided into four ten groups including control patient, training patient, healthy control, healthy training. The exercise group participated in a six-week continuous aerobic exercise program. The patient group was diagnosed with Alzheimer's disease by intraperitoneal injection of scopolamine for 14 days, and after ensuring the induction of Alzheimer's disease using the novel object recognition test, the training group participated in a six-week continuous aerobic training program.
Results; Based on the results after six weeks of continuous aerobic training, according to the measurement of the tissue components in the soleus and EDL muscles of the healthy group of rats under training, it showed a slight increase in the extent of the tissue parenchyma and the diameter of the muscle fibers compared to the healthy control group, but these changes were not significant. The quantification of the extent of the tissue components in the soleus and EDL muscles of the studied rats showed a significant decrease in the muscle parenchyma and also a significant decrease in the average diameter of the muscle fibers in the patient group compared to the healthy control group (p<0.01). The area of the muscle parenchyma and the average diameter of the soleus and EDL muscle fibers in the mice of the patient group under training compared to the mice of the patient group showed a significant increase in tissue (p<0.05) and the amount of tissue edema and the presence of connective tissue showed a significant decrease (p<0.01 and p<0.05).
Conclusion: According to the findings, it seems that sports activities have positive effects on sarcopenia disease and myofibril changes, as well as the sports performance of rats with Alzheimer's disease.
Keywords: continuous aerobic exercises, Alzheimer's, sarcopenia, muscle myofibril
Background and Purpose; Sarcopenia is a progressive and generalized skeletal muscle disorder that involves rapid loss of muscle mass and function. The purpose of this study was to investigate the effect of continuous aerobic exercise on sarcopenia, changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's disease, to investigate the effect of physical activity on reducing sarcopenia and changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's should be measured.
Materials and Methods; In the present study, 40 aged Wistar rats with an average weight of 300 grams. The rats were randomly divided into four ten groups including control patient, training patient, healthy control, healthy training. The exercise group participated in a six-week continuous aerobic exercise program. The patient group was diagnosed with Alzheimer's disease by intraperitoneal injection of scopolamine for 14 days, and after ensuring the induction of Alzheimer's disease using the novel object recognition test, the training group participated in a six-week continuous aerobic training program.
Results; Based on the results after six weeks of continuous aerobic training, according to the measurement of the tissue components in the soleus and EDL muscles of the healthy group of rats under training, it showed a slight increase in the extent of the tissue parenchyma and the diameter of the muscle fibers compared to the healthy control group, but these changes were not significant. The quantification of the extent of the tissue components in the soleus and EDL muscles of the studied rats showed a significant decrease in the muscle parenchyma and also a significant decrease in the average diameter of the muscle fibers in the patient group compared to the healthy control group (p<0.01). The area of the muscle parenchyma and the average diameter of the soleus and EDL muscle fibers in the mice of the patient group under training compared to the mice of the patient group showed a significant increase in tissue (p<0.05) and the amount of tissue edema and the presence of connective tissue showed a significant decrease (p<0.01 and p<0.05).
Conclusion: According to the findings, it seems that sports activities have positive effects on sarcopenia disease and myofibril changes, as well as the sports performance of rats with Alzheimer's disease.
Dr Fatemeh Kazeminasab, Miss Motahareh Mohebinejad, Dr Karim Azali Alamdari,
Volume 0, Issue 0 (11-2019)
Abstract
Background and purpose: Excessive fat deposition is associated with cardiovascular diseases, diabetes as well as hypertension. The aim of this study was to determine the net effect size of high intensity interval training (HIIT) on some factors associated with insulin sensitivity in adults with overweight and obesity.
Materials and methods: A search for English articles was conducted in Web of Science, Scopus, and PubMed databases without limiting the year of publication until February 2023. To calculate the effect size, WMD and 95% confidence interval were calculated using random effect model. Fixed effect model meta regression was used to determine treatment effects associations with other variables.
Results: In total, 13 studies with 446 adults with overweight and obesity (149 females, and 317 males) with 24.7-57 years old were included in the present meta-analysis. The results showed that HIIT caused a significant decrease in fasting glucose [WMD=-8.65 mg/dL, P=0.002], fasting insulin [WMD=-1.88 U/L P=0.005], and diastolic blood pressure (DBP) [WMD=-3.33 mmHg. Weak correlations were observed in between HIIT’s net effect on DBP and insulin (r=-0.32, p=0.019) as well as with subjects’ age (r=-0.29, p=0.037) respectively in meta-regression assessments.
Conclusion: The rate of DBP reduction is sharper and these changes are also correlated with age. Therefore, HIIT is suggested as a Non-pharmacological Approach to prevent against future cardiometabolic risk factors in this population.
Zahra Mohammadpour , Karim Azali Alamdari, Azam Zarneshan,
Volume 18, Issue 20 (11-2020)
Abstract
There is a large necessity for met analytic investigation of the blood pressure (BP) response to aquatic exercise training (AET) in hypertensive patients. was to quantify BP changes after (AET) and identify subgroups exhibiting the largest changes. Clinical trials investigating the impact of AET on hypertensive patients published in English and Persian research journals up to July 2020 were searched from google scholar, Pubmed, Science Direct, SID and magiran. Finally, 12 trials were analyzed to quantify effect sizes (difference in means with 95% confidence intervals) using Random Effects model. Subgroup analyses included gender, menopause status, number of sessions per week and training intensity categories. Simple random-effects meta-regression analysis (methods of moment approach) was performed to investigate the association between changes in BP and changes in both training duration and water temperature. AET decreased both SBP and DBP; -12/29 and -5/69 mm Hg respectively, regardless to hypertensive subjects’ characteristics, training session count per week and water temperature. A tendency for larger reductions in SBP with greater reductions in body weight (β1=0.38, P=0.003) and water temperature (β1=1-.29, P=0.012) were observed after AET. In addition, the magnitude of the effect of AET on both SBP and DBP were significant in all subgroups (except for SBP in males) (P <0.05). AET remarkably lowers both SBP and DBP in hypertensive emphasizing on the clinical importance of AET in controlling hypertension. Likewise; it seems more BP reductions could be inevitable in patients with lower body weight and also elevations in water temperature (up to 38 °C). However, more clinical trials still need to be provided because of the lack of evidence and also heterogeneity of the results.
Dr Ali Asghar Ravasi, Dr Mousa Khalafi, Dr Karim Azali Alamdari,
Volume 19, Issue 22 (12-2021)
Abstract
Background and objective: Effects of exercise training on metabolic disorders through modifications in fibroblast growth factor -21 (FGF-21) level are controversial. Therefore, the aim of study was to determine the quantitative effect of exercise training protocols on serum FGF-21 level in adults with metabolic disorders. Methods: A systematic search of the published Persian or English-language studies from PubMed and Google Scholar databases up to march 2021 was done and standardized mean differences (SMDs) were calculated using random-effects models. Results: a total of 14 studies (aerobic training=3, resistance training=3, HIIT=4, concurrent training=4) including on 19 interventions conducted on 503 subjects (with overweight, obesity, type 2 diabetes, metabolic syndrome and or fatty liver disease) were eligible to include in the meta-analysis. However, because of the heterogeneity, the final quantitative impact of 16 interventions was calculated as a declining serum FGF21 level after training [SMD=-0.44(CI: -0.65 to -0.22) p=0.001] which had no correlation with subjects age(p=0.10) or BMI(p=0.50) level. Conclusion: exercise training protocols are efficient tools for a remarkable decrease in serum FGF-21 in patients with metabolic disorders which seems to lead to more beneficial effects on metabolic disturbances. However, more clinical trials are still warranted in this area considering the role of exercise components such as exercise intensity and type
Fatemeh Kazeminasab, Mohammad Hossein Mahboobi, Karim Azali Alamdari,
Volume 22, Issue 27 (8-2024)
Abstract
The purpose of this study was to investigate the impact of combining aerobic exercise (AE) and vegetarian diet (VD) on blood pressure and body weight in adults with overweight and obesity. The PubMed, Web of Science, Scopus, and Google scholar databases were searched until February 2023 for English articles, and 1065 articles were found. Meta-analyses were performed to compare the impact of aerobic exercise and vegetarian diet on body weight, blood pressure in adults with overweight and obesity. Data analysis was performed using random effect model and weighted mean differences (WMD). The results of meta-analysis of 25 studies with 10192 adults showed that combined aerobic exercise and vegetarian diet significantly decreased in body weight [WMD=-4.63, p=0.001] , systolic blood pressure [WMD=-6.94, p=0.001] , and diastolic blood pressure [WMD=-4.5, p=0.001] , in adults with overweight and obesity. Aerobic training alongside vegetarian diet as a non-medication approach for weight loss and blood pressure control in adults with overweight and/or obesity. In addition, aerobic exercise and vegetarian diet with both types of duration (less than 12 weeks and more than 12 weeks) cause a significant decrease in blood pressure in adults with overweight and obesity.
