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Showing 2 results for Nikooie

Dr Rohollh Nikooie, Msr Bahareh Hajmalek, Dr Dariush Moflehi, Mr Amir Nejad Vaziri,
Volume 0, Issue 0 (11-2019)
Abstract

Background: This semi-experimental study aimed to investigate the effect of insulin resistance on substrate selection during exercise in obese diabetic women.
Methods: 24 inactive obese women, including control (C; n=8,BMI=31.03±1.18), non-insulin resistance (NIR;n=8,BMI=30.91±0.78), and insulin resistance (IR, n=8,BMI=31.57±0.91) groups, were purposely selected and performed a standard incremental test with an initial workload of 50 W and increased in the workload of 20 W every three minutes. Respiratory gases were collected throughout the test. Cross-over point (COP), a point at which the metabolic substrate changes from fat to carbohydrates, and FATmax point at which fat has the highest contribution to energy supply, were determined. Heart rate and oxygen consumption corresponding to COP and FATmax, points were calculated and compared among the groups using one-way analysis of variance (ANOVA).
Results: In both diabetic groups, heart rate (P<0.001) and oxygen consumption (P<0.001) corresponding to COP were significantly lower compared to the C. Both variables had lower values in the IR compared to the NIR (P<0.001). In both diabetic groups, oxygen consumption corresponding to the FATmax point was significantly lower compared to the C (P<0.001) and had lower values in IR compared to the NIR (P<0.001). Conclusion: In general, the results of the present study showed that insulin resistance is associated with more reliance on carbohydrates and diminished fat oxidation at submaximal exercise intensities.
 
Mrs Nasim Sivandi, Dr Rohollah Nikooie, Dr Darioush Moflehi,
Volume 21, Issue 25 (9-2023)
Abstract

Amino acid taurine can increase the utilization of fatty acids and stimulation of lipolysis through augmentation of the expression of genes related to regulation of energy metabolism. The purpose of this study was to investigate the effect of taurine supplement on lipid oxidation and substrate selection during exercise in obese women. 15 obese women (Body weight: 34.53 ± 6.33 (kg), BMI: 33.12 ± 3.23 (kg/m2)) performed a standard incremental test before and after 21 days of taurine supplementation (50 mg/kg). Blood samples were collected before and after the test and breath by breath mesurment of respiratory parameters were done throughout the test. FATmax (as the point at which fat contributes the most to the consumed energy) and Cross over point (as the point at which the predominant fuel changes from fat to carbohydrates, COP) were calculated. Heart rate, workload, and oxygen consumption corresponding to FATmax and COP were determined and compared between attempts before and after supplement consumption using independent t-test and analysis of variance with repeated measures. Following taurine consumption for 21 days, the changes in serum levels of estrogen and progesterone hormones, maximum oxygen consumption, and time to exhustion during incremental exercise test were significantly higher than before supplement consumption. Nevertjeless, the consumption of supplement had no effect on heart rate, workload and oxygen consumption corresponding to FATmax and COP points. Despite the increase in performance variables during exercise, taurine supplementation has no effect on substrate selection during exercise in obese women.


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