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Mr Saeid Eimani Zadeh, Dr Mansoor Sahebzamani, Dr Mohamad Taghi Amiri Khorasani,
Volume 13, Issue 10 (10-2015)
Abstract

The purpose of this study was to investigate the effect of soccer specific functional fatigue on hip and knee
joints angles during landing in professional players.15 soccer players with at least 2 years experience in
Kerman soccer clubs were selected randomly. To evaluate the lower extremity kinematics following
jumping and soccer specific- heading, three cameras (with50Hz) were used. To cause fatigue in subjects,
specific functional protocol similar to specific bangsbo soccer was used and Quantic sport v21 soft ware
was administrated for kinematic analysis of the recorded films. To statistical analyzing of data, descriptive
statistical methods, and paired-t test were administrated at α=0.05.Finding revealed that hip and knee
angles in sagittal and frontal plane in landing is influenced by functional fatigue. This results has been
reducing knee and hip flexion angles and increased varus in knee joint. Results demonstrated a more
erect landing posture due to a decrease in hip and knee flexion angles in the post fatigue condition.
However, functional fatigue significantly decrease lower extremity control ability in male soccer player
during landing.


Mr Mojtaba Ashrostaghi, Dr Elham Shirzad,
Volume 13, Issue 10 (10-2015)
Abstract

Take-off is the critical phase of the long jump event. The aim of this study was to explore the relationships
between different variables and success in take-off. 37 trials performed by 8 long jumper, participants in
fourth indoor Asian senior athletics championships held in Tehran, with personal best average of 7.68±0.28
meter were recorded at 300 Hz. Five speed-related, five technical and four strength-related variables as well
as an anthropometric variable were measured using motion analysis software. More gain in vertical velocity
and less loss of horizontal velocity are considered as two criteria of take-off success and their relationships
with other variables were determined through correlation and regression analysis. Significant level of 0.05
was set. Some variables of all four groups were significantly correlated with success criteria. These variables
along with some others were entered in regression equations. The results emphasized on dominant role of
the technique and approach velocity and represented the effect of anthropometric characteristics on success
in takeoff. Furthermore eccentric strength of knee extensors was shown as the main strength factor in this
performance.


Kamran Johari, Mohammad Hosein Alizadeh, Amir Hosein Barati,
Volume 15, Issue 14 (10-2017)
Abstract

The present study aimed to examine the effects of FIFA 11+ comprehensive warm-up program for referees on dynamic balance among male Iranian football referees and assistant referees. Fifty-two football referees and assistant referees who had no previous injury voluntarily participated in the present study. They were randomly assigned into an intervention group and a control one (26 participants each group). The intervention participants took part in a 17-week FIFA 11+ comprehensive warm-up program for referees while the control group performed their usual warm-up trainings during a half season. In order to estimate the dynamic balance of the referees in the pre-test and post-test, Y Balance Test was used. The collected data were analyzed using Descriptive statistics and ANOVA. The results of the present study indicated that the intervention and the control groups were significantly different in terms of dynamic balance in anterior and posteromedial directions and also the referees’ overall balance score before and after the study. However, no significant between them was observed in posteriolateral direction. According to the findings of the present study, it can be concluded that the FIFA 11+ comprehensive warm-up program for referees could improve the referees’ and the assistant referees’ dynamic balance.
Faezeh Mohammadi Sanjani , Masoomeh Shojaei, Afkham Daneshfar,
Volume 15, Issue 14 (10-2017)
Abstract

Introduction and purpose: Reaching movement is one of the common task for assessing learning mechanism and is daily task in human life, improvement in postural stability can influence the function of this task. In this term, the aim of current study was to compare constant (simple reaction time) and variable random practice (choice reaction time) on the improvement of anticipatory postural adjustment during reaching task in healthy people. Methodology: Sixteen right handed women with the mean age of (27.18±3.18) participated in this study. For measuring magnitude of anticipatory postural control, centre of pressure displacement and centre of pressure velocity were evaluated by using force plate before reaching movement. Results: The results of mixed variance analysis in significant level of p<0.05 showed that random variable practice increased cop displacement and velocity before reaching task, but this increase wasn’t significant in acquisition and retention tests. Discussion and Conclusion: Therefore according to the results of this study, random variable practice improved anticipatory postural adjustment. Based on these results, effect of this practice on anticipatory postural control can be considered in rehabilitation programs.

Mr Nemat Allah Behboodian, Mr Jamal Khajeh Ali, Dr Amir Letafat Kar,
Volume 15, Issue 14 (10-2017)
Abstract

Due to the necessity of screening injury the aim of this study was to screen the scores of Functional movement screening tests in active and inactive subject . The study population consisted of University Students aged 18 to 25 years out of which 50 students (25 active and 25 inactive) were selected. Functional Movement Screen by Cook were used for functional screening. After the normality of the overall scores for FMS, Independed-Samples T-Test was used in SPSS (version 16) to analyze the data at significant level of 0/05. According to the findings, overall scores of FMS was significantly different between active and inactive subjects (P=0/001). Cut-off point of 17 was obtained for all subjects. There was no significant difference in shoulder mobility and straight leg raise test scores in the active and inactive people but there was significant difference among the scores of other five tests This prospective study shows that due to the overall score FMS inactive people than in active people are more prone to injury.
Mohadse Salehi Sarbizhan, Amir Letafatkar, Mehdi Khaleghi,
Volume 16, Issue 16 (12-2018)
Abstract

The most common side effect of physical activity is the risk of musculoskeletal damage, that anterior cruciate ligament injury is the most common one. Purpose of the study is comparing the effect of six weeks of comprehensive injury prevention training on anterior cruciate ligament with internal and external feedback on the proprioception and knee function of active female university students. Forty five active female university students aged 18-25 years were volunteered and randomly assigned to three groups (internal, external and control) and they performed the protocol three times a week for six weeks. Proprioception and function of the knee joint were measured using goniometer and functional tests in two stages  namely pre-test and post-test. Statistical analysis of covariance, paired t test and Tukey's post hoc tests were used for statistical analysis with a significant level of p≤0.05. Overall results of the study showed that the present exercise protocol with internal and external feedback had a significant effect on the proprioception of p≤0.001 and p=0.000 for the knee performance and there was no significant difference between the two training groups. Regarding the results of the study, it is suggested that the present training protocol be addressed by coaches and sport sciences specialists as a complementary tool and method, along with other training methods, for those who are prone to damage to the anterior cruciate ligament.

Mohammad Reza Mahmoudkhani, Hooman Minoonejad, Reza Rajabi, Amir Hossein Barati,
Volume 16, Issue 16 (12-2018)
Abstract

Judo is one of the most popular martial arts in the world. Researchers reported a higher risk of injuries during training rather than the time of competition. So, the safe and effective training methods should be considered. As development and application of injury prevention approaches and athletic performance enhancement is necessary, the purpose of this study was to investigate the effect of 8-week Judo Specific Functional Training on the injury risk factors and athletic performance in non-elite male judokas. 46 non-elite judokas participated in this study. Subjects were randomly divided into two groups of experimental (23:N) and control (23:N). For a period of 8 weeks, the experimental group attended a special judo functional training program designed by the researchers. At the same time, the control group participated in the usual judo training program presented by the coaches. The exercises were performed 3 sessions per week and 90 minutes per session. The subjects participated in pre- and post-tests. After data collection, in order to approve data normality and compare the variables, Shapiro-wilk, ANCOVA analysis was implemented at the significant level (p≤0.05) using SPSS version 21. The results showed that scores of functional movement screening (p=0.001), upper extremity Y balance test (p=0.001), vertical jump (p=0.001) and special judo fitness test (p=0.001) significantly increased among the experimental group in comparison to the Control group. This Judo specific functional training program simultaneously modifies or decreases the injury risk factors and improves the athletic performance and has more efficiency and effectiveness rather than the usual judo training program.    


A.a Jafarnezhadgero, F Ghorbanlou, S.m Alavi-Mehr, M Majlesi,
Volume 17, Issue 18 (12-2019)
Abstract

Genu varus is one of the malalignment of the lower limbs, the failure to correct it leads to secondary abnormalities in adulthood. The purpose of this study was to investigate the effects of a corrective exercise program on ground reaction forces, loading rates, impulses and free moment during stance phase of walking. 17 children with genu varus were volunteered to participate in this study (Age:11.71±1.68 years, Height:1.40±0.09 meter, Weight:35.14±11.47 Kg, and BMI:17.49±3.61Kg/M2). Ground reaction forces were recorded with two Kisler force plates during pre and post-test. At the dominant limb, the amount of time to peak in the mediolateral ground reaction force component during heel contact decreased by of 61.90% (P=0.011). Also, the time to peak of the vertical ground reaction force component during mid-stance tend to increase significantly by 11.47% during the post-test compared to the pre-test (P=0.063). The values of peak ground reaction force components, loading rate, impulse and free moment did not show any significant differences between pre and post-test. The findings showed that the corrective exercise trainings used in the present study had the most effect on the time to peak components of the GRF, but there were no significant effects on the loading rate, impulses, and free moment components. The corrective exercises used in the present study have had the most effect on the time to peak of ground reaction forces and improve them. On the other hand, these exercises did not have any significant effect on the vertical loading rate, impact and free moment values.

R Shiri, H Nikbakht, M Gholami, Kh Ebrahim,
Volume 18, Issue 19 (7-2020)
Abstract

Time under Tension of muscle is one of the variables of strength training that contributes to its adaptation. The present study was conducted the effects of six weeks of resistance training with the varying Time under Tension of muscle on VEGF and endosotene serum levels  in healthy young women. This study was conducted on 20 female students (22.65±2.03years) Subjects were randomly and equally assigned to two groups with a Time under Tension of 1s- 1s(Normal Speed Contraction) and 3s- 3s (slow Speed Contraction). The exercise load was the same in both groups and resistance training was done in a circular manner for six weeks, three days a week in eight stations. Blood samples were taken from the subjects to study  research variables before the training period and 48h after the last session of the training. Data were analyzed by covariance analysis at a significant level of P≤0.05. There was no significant difference between the serum levels of VEGF and endostein in both groups (P≥0.05). In the strength test, the  SSC group experienced increase power further. However, there was no difference between the two groups in indicators related to angiogenesis for six weeks and  most probably, for this indicator needed more training time, but  practice with more Time under Tension (3s- 3s) can lead to increase power further.
 

N Jamali, Kh Khayambashi, Sh Lenjannejadian, H Esmaeili,
Volume 18, Issue 19 (7-2020)
Abstract

Although hip muscle strengthening has been reported as an effective way to decrease PFPS symptoms, however its effect on lower extremity kinematics is less clear. The current study was done with the aim of investigating the effect of hip abductor and external rotator muscles strengthening exercises on lower extremity kinematics in static and dynamic states. In a randomized controlled trial, 33 patients with patellofemoral pain (PFP) were randomly assigned into exercise (8 female, 30±6.8 y/o, 23.8±2.6 BMI and 8 male, 31.2±7 y/o, 25.6±1.5 BMI) and control (9 female, 29.9±7.3 y/o, 23.2±3.2 BMI and 8 male, 32±6 y/o, 25.5±1.9 BMI) groups. In exercise group they received hip abductor and external rotator strengthening exercises by thera-band 3 times per week for 12 weeks under supervision by a physiotherapist. The control group did not receive any training intervention. Hip muscles strength and kinematics in static and dynamic states, were assessed at baseline and post-intervention. Repeated measures ANOVA by using SPSS were applied to assess the effects of the exercise on measured variables (α=0/05). After 12 weeks of strengthening program, by an increase in abductor muscle strength in women from 19.6 to 26.4 %BW (P=0.000) and in men from 29.9 to 38.1 %BW (P=0.003), and in hip external rotator muscles in women from 13.2 to 16.9 %BW (P=0.024) and in men from 26.3 to 34.9 %BW (P=0.000), dynamic knee valgus angle during single-legged squat improved in women from 170 to 174.6 degrees (P=0.018) and in men from 171.8 to 176.8 degrees (P=0.017) and contralateral pelvic drop angle during stair descending improved only in women from 7.9 to 6 degrees (P=0.04) in the exercise group. No significant difference was observed at quadriceps angle (P≥0.05). The findings suggest that hip muscles strengthening can alter the lower extremity kinematics, in dynamic state, at the frontal plane, and it might be said that due to these changes following hip abductor and external rotator muscles strengthening exercises by thera-band, the symptoms of PFP improve more consistent.

Soroush Shah Hosseini, Amir Hossein Barati, Mohammad Hossein Nasermeli, Mohsen Moradi,
Volume 18, Issue 20 (11-2020)
Abstract

Given that more than 50 percent of patellofemoral pain syndrome include of overuse injuries, the aim of this study was to compare the vastus medialis muscle activity in individuals with patellofemoral pain syndrome after a period of strength and flexibility training with and without the electrophysiological feedback. A total of 30 subjects (15 men and 15 women) participated in this study. Subjects were divided into three group's control, therapeutic and therapeutic with electrophysiological feedback. One-way ANOVA was used to compare the activity of vastus medialis muscle in between groups. The results of this study showed that there was a significant difference between the groups in the activity of the vastus medialis muscle activity (P <0.05). The results of Tukey's post hoc test for intra-group comparisons showed that there was a significant difference between the control group with the therapeutic group (P = 0.024), the control group with the therapeutic group and the electrophysiological feedback (P=0.028) and the therapeutic group with the therapeutic group and the electrophysiological feedback (P<0.001). Conclusion: Regarding the results of this study, therapeutic exercises with electrophysiological feedback have a greater effect on the activity of vastus medialis than the therapeutic group in patients with patellofemoral pain syndrome.

, , , ,
Volume 19, Issue 22 (12-2021)
Abstract

Aim: Neuropathy control and management is an objective in therapeutic exercises prescribed for patients with Type 2 diabetic peripheral neuropathy. We examined the effects of 12-week integrated exercises (IE) on glycemic control and peripheral sensation criteria in patients with diabetic neuropathy. Methods: Based on scores of MNSI, we assigned 40 patients into two equal paired random groups (control vs. IE). Pre and post-tests were administered before and after three months of intervention for 3 sessions per week with a time of 60 minutes in the first week and gradually increased with the duration and volume of training to 90 minutes in the final session.
 Results: Repeated measures ANOVA showed no significant interaction between FBS of the groups (P = .26), but significant interactions were observed between the levels of 2 hrs pp G , 4 pm G, HbA1c, Diapason, Monofilament, and Thermofeel in favor of the IE group (P <.05). Conclusion: At the beginning of the IE, we used massage and foam roller to release pain, and improve blood circulation as well as sensation in the neuropathic areas. This may have helped the patients perform the aerobic and resistance exercises more easily Therefore, better glycemic control and peripheral sensation was achieved. Verification of the long-term effects of this training strategy requires further study.


Vahideh Ranjbari, Mehdi Rafei Borujeni, Shahram Lenjannejadian,
Volume 20, Issue 23 (9-2022)
Abstract

Introduction and aim: The kinematic analysis of elite athletes’ performance is an important method to determine effective parameters of sport performances. The purpose of the present study was to compare kinematic characteristics of the upper extremity in adolescence and adult players in three-step shoot in Handball. Methods: Nine elite adult handball players working in the Super League (23.55 ± 2.69 years) and ten teen handball players (16.4 ± 0.69 years) participated in this study. The pictures related to the final stage of the shoot were recorded three dimensionally and analyzed by a graphic interface in MATLAB software. The data related to the angular position, angular velocity and peak angular velocity and position corresponding to the upper limb joints of athletes, including the wrist, elbow and shoulder were obtained. Statistical data were used for analysis through student t-test for two independent groups with significance level p ≥ 0.05 in order to compare two groups. Findings: There were significant differences between two groups in angular position of elbow joint during extension at maximum angular velocity and linear velocity of the ball at the time of the release. Conclusion: it seems that other factors than cinematic characteristics such as anthropometric characteristics along with muscle strength in adult are important to get the maximum velocity of ball release. 
, , , ,
Volume 20, Issue 23 (9-2022)
Abstract

Background and Aim: Given the widespread trade in some sports, a misjudging decision can not only have huge financial consequences for competitors, but also affect the event itself. The overall purpose of this study was to determine the role of information technology and perceived organizational support on the performance of the referees of the 2018 FIFA World Cup in Russia: to investigate the mediating role of job satisfaction and self-efficacy. Methods: This is a descriptive research, correlation model, based on structural equation modeling, and its type. The statistical population of the study consisted of all referees and assistant referees present at the 2018 FIFA World Cup in Russia, of which 111 referees were 35 middle referees, 63 assistant referees and 13 video assistant referees. Results: The results showed that information technology, perceived organizational support and self-interest have a significant positive effect on the performance of the referees of the 2018 FIFA World Cup in Russia. Job satisfaction does not have a significant effect on the performance of the referees of the 2018 FIFA World Cup in Russia. Conclusion: Information technology is an effective and facilitating factor in arbitrators' decisions, so it is suggested to provide technological infrastructure in order to improve the instant decisions of arbitrators on a larger scale.
, , ,
Volume 20, Issue 23 (9-2022)
Abstract

Considering the prevalence of pain and disability in the knee joint, the present study investigated the effect of core stability training with improving knee joint proprioception on balance, pain and functional disability of women with chronic knee pain. 20 women aged 30 to 50 with chronic knee pain were placed in two experimental and control groups. To measure static and dynamic balance, pain and functional disability, the stork balance tests, Y, VAS and VOMACK questionnaire were used, respectively. Exercises were followed for eight weeks in the experimental group. To evaluate the research hypotheses, the analysis of variance test with repeated measurements was used in spss software version 24. The results showed that before the exercise protocol, there was no significant difference between the control and experimental groups in any of the measured variables. While the eight-week training protocol caused a significant difference in static and dynamic balance, functional disability and pain between the control and experimental groups. Therefore, core stability training with improving knee joint proprioception increase balance in people with chronic knee pain, which can reduce the risk of falling in these people and improve the quality of life by improving pain and functional disability.
 

Saeed Arsham, Tahereh Rahimi, Malihe Sarabandi,
Volume 20, Issue 23 (9-2022)
Abstract

Introduction and aim: Physical activity and especially the motor proficiency of children have been studied from different aspects. The purpose of the present study was to determine the correlation among Functional Movement Screening scores with motor proficiency and physical activity levels of children aged 10 to 13 (Mean=11.72, SD=0.932) in Tehran province. Methods: In this descriptive study of correlation, all the children of primary schools in Tehran province were considered as the study population, from which 94 girls were selected by cluster random method. Their motor proficiency, physical activity levels, and functional movement were evaluated with Bruininks Oseretsky test-Short Form (BOT-2), International Physical Activity Questionnaire- Short Form (IPAQ-SF), and Functional Movement Screening test (FMS) respectively. Findings: The results of the Pearson correlation coefficient test showed that there is a significant relationship between the scores of the children's functional movement screening test and their BOT-2 total score (P=0.000), but the correlation between the total score of the functional movement screening test and the total score of the physical activity levels was not significant (P=0.267). Conclusion: In general, due to the existence of a significant relationship between functional movement and motor proficiency, the next step is to use early interventions and study their effect on improving children's performance and motor proficiency.

Mr Mojtaba Sadeghi, Dr Hamid Rajabi, Dr Farzad Nazem,
Volume 21, Issue 25 (9-2023)
Abstract

The purpose of this study was determine the effect of upper body plyometric training on anaerobic power and record of 25 meters front crawl performance in 10 years old swimmer boys. 16 swimmer boys chosen voluntarily (The mean age was 9.9 ± 0.7 years ، weight 45.9 ±9 kg , Height 149.8 ± 5 cm، BMI  is 19.20 ± 3 Kg / m 2  ) And Subjects divided into two groups of training (n=8) and control(n=8).Before and after the implementation of the protocol investigate test 25 meters front crawl performance  at the distance 10, 20 and 25  metrs  and the number of hand strocke to check the performance of the swimming also anaerobic hand wingiting test function was evaluated. To analyze data, used the covariance test.The results showed six weeks upper body plyometric training Performance Indicators an hands Front crawl Including Peak power increased Significantly (18%) but the average power increase (7%) was not significant (p>0.05). Also, Swimming performance at of 10 meters) 8% (,10 to 20)6%( and 25 meters distance( 3/80%) growth in compare to control group that was significant(p <0.05) As well as in the number of hand strocke, Plyometric training group although had growth in swim 10 meters (11%), 10-20 meters (7.5%) and in 25 meters distance (5.33%) but the isnt significance (p>0.05). results indicate that six week upper body plyometric traning to an increase and improvement in the measured parameters, and can be used as a complementary training method in young swimmers.

Mrs Sedigheh Nosrati Abarghoee, Mrs Fatemeh Nematian, Dr Roohangiz Norouzinia, Mrs Fatemeh Edalat, Mrs Dorrin Nikbakht,
Volume 21, Issue 25 (9-2023)
Abstract

Nurses, especially nurses in the intensive care unit, experience significant job stress that can endanger their health and cause a decrease in their sleep quality and happiness, and as a result, the quality of care for patients, and considering that the working conditions of the nurses in the intensive care unit Especially, it is in a way that increases emotional pressure and sad mood. Therefore, this study was conducted with the aim of determining the effect of online Pilates exercise on the quality of sleep and happiness of nurses in the intensive care unit.
The study was a quasi-experimental type of pre-test-post-test with two intervention and control groups and was conducted on 70 female nurses with an average age of 30.14±3.26. The intervention was held online in 8 sessions (3 sessions per week, 50 minutes in the afternoon in the form of warm-up exercises, main exercises and cooling down). Data were collected using the Pittsburgh Sleep Quality and Oxford Happiness Questionnaires and analyzed with spss 23 software and chi-square, t-test, and Mann-Whitney tests. At the beginning of the study, there was no statistically significant difference between the two groups. But at the end of the intervention, the average score of total sleep quality (p=0.045) and happiness (p=0.0001) showed a significant improvement in the intervention group.To improve physical and mental health, improve the quality of life, sleep and happiness, classical Pilates exercise can be recommended to be included in daily programs.

Dr Malihe Aveseh, Dr Maryam Koushkie Jahromi, Dr Javad Nemati, Dr Saeed Esmaeili Mahani,
Volume 21, Issue 25 (9-2023)
Abstract

Lactate has been recently considered as a signaling factor involved in metabolism. The aim of this study was to investigate the role of lactate entrance into the brain on endurance training-induced adaptations in lipid oxidation. 
24 male rats (age: 8 weeks, weight: 197 ± 21 g) were divided into control (C), trained (T), and traind+4-CIN (T+4-CIN, which experienced the inhibition of lactate entrance into the brain during exercise). All animals performed a single session of acute endurance exercise following their 12-weeks training protocol.  Free fatty acids (FFA) and triglyceride content in plasma and adipose tissue and cAMP and Inositol triphosphate (PI3) content in epididymal fat were measured immediately after acute exercise using ELISA and were compared among the groups by one-way analysis of variance (ANOVA).
Acute exercise significantly increased lactate concentration in cerebrospinal fluid (SCF) in both T and T+4-CIN compared to the C group. Lactate concentration was slightly lower in T + 4-CIN compared to the T.  Immediately after acute endurance training, a significant decrease of 61 and 31% in plasma triglyceride levels, a significant decrease of 39 and 26% in adipose tissue triglyceride levels, a significant increase of 125 and 56% in plasma FFA levels, a significant increase of 217 and 125% increase in FFA plasma levels, a significant increase of 87 and 41% in adipose tissue cAMP levels, and a significant increase of 90 and 49% in adipose tissue inositol triphosphate levels was observed in the T and T+4-CIN compared to the control group, respectively (all P < 0.01). Plasma triglyceride and adipose tissue levels in the 4-CIN + training group were significantly higher and plasma and adipose tissue FFA levels were significantly lower (all P < 0.05) than the values found in the T group.  In conclusion, the results of the present study showed that lactate can be effective on endurance training-induced adaptations in lipid oxidation due to its action in the brain.

Mr Reza Asadi, Dr Mohammad Reza Kordi, Dr Fatemeh Shabkhiz,
Volume 21, Issue 25 (9-2023)
Abstract

Neurodegenerative processes play an important role in the progression of MS. Appropriate exercise training and living in an enriched environment (EE) can improve or prevent the progression of the disease through the secretion of some neurodevelopmental factors in the hippocampus, including irisin and the neutrophic factor derived from the mouse. The aim of the present study was to investigate the effect of 4 weeks of aerobic and resistance training and EE on irisin protein and hippocampus BDNF levels in female C57BL6 mice with experimental autoimmune encephalomyelitis (EAE). 50 female mice (age 8 weeks, average weight 18 ± 2 grams) were randomly divided into five equal groups (10 mice in each group): 1- healthy control, 2- control + EAE, 3- resistance activity + EAE, 4- Aerobic activity + EAE and 5- EE + EAE. The first and second weeks of adaptation to the environment and then induction of EAE were performed. The training groups trained 5 days a week for half an hour a day for 4 weeks, and the EE group was transferred to its equipped cage. 48 hours after the last training session, the mice were anesthetized and then dissected and tissue removed. The ELISA method was used to measure the amounts of proteins, and the analysis of variance and Tukey's t-test were used to determine the differences between the research variables. All analyzes were performed at a significance level of 0.05 and with SPSS22 software. Hippocampal BDNF expression was increased in all three training groups compared to the EAE control group. This increase in the EE and resistance training group was significant compared to both the EAE control group and the swimming training group. Also, hippocampal irisin expression increased in all three training groups compared to the EAE control group, and this increase was significant in the EE and resistance training groups. Also, the expression of irisin in the EE group increased more than the two aerobic swimming and resistance training groups, and this increase was proportional to It was meaningful to the swimming aerobic training group. It seems that EE and resistance training can increase the secretion of nerve growth factors such as irisin and BDNF and thus help to improve MS disease.


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