Search published articles


Showing 2 results for Dashty khavidaki

, Dr , Dr , Dr Mohammad Hassaan Dashty Khavidaki,
Volume 0, Issue 0 (11-2019)
Abstract

Introduction and purpose:Alzheimer's disease is one of the most common diseases of brain cell degeneration, one of its symptoms is depression.The aim of this study was the effect of a course of exercise training on the level of depression and oxidative stress factor changes in the hippocampus and prefrontal cortex of rats with Alzheimer's disease.
Methodology:For this purpose,40 8-week-old male Wistar rats with an average weight of237±33grams were randomly divided into four groups of 10: control,exercise,Alzheimer's,and exercise+Alzheimer's.The exercise protocol included 2 weeks of running on a treadmill at a speed of12 m/min and for 30minutes in each session. At the end of the training period, feeding sensation suppression and tail suspension tests were performed to estimate depression as well as hippocampal and prefrontal malondialdehyde levels using the Bradford method.
Results:The results showed that exercise training significantly reduced the rate of depression in Novelty-suppressed feeding test and suspension test in rats with Alzheimer's disease.Also,exercise training significantly reduced malondialdehyde levels in the hippocampus of rats with Alzheimer's disease while no significant difference was observed in the prefrontal.
Discussion It seems that sports activity can create immunity against Alzheimer's disease and is probably effective in preventing the occurrence of depression in Alzheimer's patients.
 
Mohsen Soltani, Ali Barzegari, Saeed Naghibi, Mohammad Hassaan Dashty Khavidaki,
Volume 21, Issue 26 (12-2023)
Abstract

This study aimed to investigate the effect of quercetin supplementation and training on myostatin and follistatin levels in the heart tissue of diabetic rats. Methods: For this purpose, 50 10-week-old male Wistar rats with an average weight of 237±33 grams were randomly divided into five groups of 10 including: healthy control, diabetes, diabetes+supplement, diabetes+exercise, and diabetes+supplement+exercise. . The training protocol includes five sessions per week for eight weeks on a treadmill without a special slope. The rodents ran for 60 minutes at a speed of 25 meters per minute in each session.and the supplement groups received 50 mg/kg quercetin daily by gavage. The results showed that the difference in myostatin levels among the groups is significant (P=0.001). There was a significant decrease in myostatin levels between exercise+supplement+diabetes group with diabetes (P=0.002). There was also a significant difference between the supplement+diabetes and exercise+diabetes groups (P=0.009). Also, the results showed that the difference in follistatin levels among the groups is significant (P=0.001). The results showed that follistatin levels in the heart tissue increased significantly between the groups of diabetes, exercise+diabetes, supplement+diabetes and exercise+supplements+diabetes with the control group (respectively: P=0.005; P=0.001; P=0.001; P = 0.001).
It seems that moderate intensity aerobic exercise and quercetin supplementation have a positive and beneficial effect on the levels of myostatin and folstatin.


Page 1 from 1     

© 2024 CC BY-NC 4.0 | Research in Sport Medicine and Technology

Designed & Developed by: Yektaweb