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Showing 2 results for Fasihi Ramandi

E Fasihi Ramandi, N Khaledi,
Volume 18, Issue 19 (7-2020)

Diabetes is a common metabolic disease. In diabetic patients glucose uptake is reduced and FGF-21 plays an important role in glucose uptake, alsoTNF-α is an inflammatory factor that increases in diabetes. The purpose of this study was to investigate the effect of 6 weeks of HIIT training on the gene expression FGF-21 in the liver and the serum TNF-α level of male diabetic rats. For this purpose, 48 Wistar rats were randomly divided into four groups Control, diabetes, high intensity interval training, and diabetes and high intensity interval training. For the induction of diabetes, peritoneal injection (Streptozotocin 50 mg/kg) was used. Training protocol including 10 set of 1-minute running (between each set of 2 minutes of rest) 3 sessions per week and was completed within 6 weeks. Finally, after the extraction of liver samples, the expression of the FGF-21 gene was measured by Real Time PCR and serum TNF-α level with ELISA kit.There was no significant change in expression of FGF-21 in any group, but the reduction of serum levels of inflammatory factors, such as TNF-α protein at the level of significance (p=0.05), and maintaining and improving the time to exhaustion, was shown by high intensity interval training (0.000).Likely the inflammatory factors of diabetes such as TNF-α have a deleterious effect on the expression and binding of FGF-21 (β-Klotho) cofactors And causes resistance to FGF-21 into various tissues of the body, such as the liver. Exercise can reduce inflammation caused by diabetes.

Reza Sabzevari Rad, Hekmat Ehsan Bakhsh, Ebrahim Fasihi Ramandi,
Volume 19, Issue 22 (12-2021)

Adiponectin plays an important role in many metabolic and heart diseases. Regulation of liver enzymes is also essential for the health of the body's organs. Therefore, this study aimed to evaluate the effect of a HIIT training period on adiponectin levels and serum concentrations of liver enzymes in obese and overweight boys. 22 obese and overweight boys were selected and randomly divided into two groups of control and experimental. The experimental group performed eight weeks of HIIT pedaling with 80% HR reserve intensity for 3 days a week. The variables of adiponectin, aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT) using kits and laboratory methods as well as aerobic power, body mass index, and fat percentage of tests in the two stages before and after Exercise protocol was also measured and covariance test was used to compare the research variables and Pearson correlation coefficient was used to examine the relationship. The results were analyzed at a significant level (P<0.05) using SPSS software version 24. Performing eight weeks of HIIT exercise using a bicycle resulted in a non-significant reduction in adiponectin (P>0.05), AST(P>0.05)   and ALP(P >0.05) enzymes. This exercise also significantly reduced ALT enzyme (P<0.05) and fat percentage (P<0.05) and increased aerobic capacity (P<0.05)
HIIT exercise strengthens aerobic power and reduces the percentage of fat and reduces the liver enzyme ALT in obese boys. Of course, more research is needed to clarify this issue.

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