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Showing 2 results for Gharakhanlou

Mrs Elmira Ahmadi, Dr Shahnaz Shahrbanian, Dr Mohamadreza Kordi, Dr Reza Gharakhanlou, Dr Gregory Pearcey,
Volume 0, Issue 0 (11-2019)
Abstract

Fatigue is one of the most common symptoms among individuals with multiple sclerosis (MS). The imbalance of inflammatory cytokines in the brain causes mental fatigue. It is believed that aerobic exercise may moderate the level of inflammation of cytokines and thus reduce mental fatigue. The present study was conducted to investigate the effect of swimming aerobic training on pro-inflammatory factors (interleukin 6) and anti-inflammatory factors (interleukin 10) to evaluate mental fatigue in the brain of female mice after EAE induction. In this research, 21 mice (8 weeks old, 18 to 20 grams) were divided into 3 groups: healthy control, EAE control, and EAE swimming aerobic exercise. The animals in the training group performed moderate-intensity swimming exercises for 4 weeks, 5 sessions per week, 30 minutes per session. The western blot method was used to analyze the research variables. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis. The results showed that there was no significant difference in the amount of IL-6 between the EAE group and swimming training, but the amount of IL10 in the swimming training group showed a significant increase compared to the EAE group. However, the ratio of IL 10/IL 6 values between the swimming training group with EAE was also not significant. It seems that moderate-intensity swimming aerobic exercises, without change in the pro-inflammatory factor, along with driving towards anti-inflammatory factors, with an increase in IL10, can lead to an improvement in the balance of the inflammatory index and a reduction in fatigue between the EAE group and swimming exercise.
A Gorzi, H Rajabi, R Gharakhanlou, M.r Dehkhoda, M Hedayati,
Volume 15, Issue 13 (9-2017)
Abstract

The purpose of this study was to investigate the effects of 8 weeks of resistance training (RT) on activity of total and A12 Type of acetyl cholinesterase in Soleus muscles of rats. 16 male wistar rats provided from Razi institute (age: 10 weeks and weight: 172.415±7.090 gr), were randomly divided to 2 groups (Control; n=8 and RT; n=8). Training group carried out 8 weeks (5 session/week) of resistance training on 1-meter height ladder (divided by 26 stairs) with loading 30% of their body weight (suspended from the tail) in the first week which was gradually increased to 200% in the last week. Training included 3 sets of 4 reps with 3 min rest between sets. 48 hrs after last session of training, Sol muscles of animals moved out under sterilized situation by cutting on posterio-lateral side of hind limb. For separating AchE subunits, we used from homogenization and electrophoresis (0/06 non-denaturaing Polyacrilamide). Acetyl cholinesterase activity was measured by Elisa kit. Independent t-test showed that there was no significant differences between training and control groups in both total (p=0.262) and A12 forms (p=0.246) of AchE in soleus muscle. The reason for insignificant differences in acetyl cholinesterase of soleus might be indicative of no complete involvement of this muscle in this type of training and therefore no responsiveness of acetyl cholinesterase activity of this muscle following resistance training. However, this should be studied in future with higher volume and intensity of training. Because the increases in AchE content by training is not excluded yet.



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