, Dr , Dr , Dr Mohammad Hassaan Dashty Khavidaki,
Volume 0, Issue 0 (11-2019)
Abstract
Introduction and purpose:Alzheimer's disease is one of the most common diseases of brain cell degeneration, one of its symptoms is depression.The aim of this study was the effect of a course of exercise training on the level of depression and oxidative stress factor changes in the hippocampus and prefrontal cortex of rats with Alzheimer's disease.
Methodology:For this purpose,40 8-week-old male Wistar rats with an average weight of237±33grams were randomly divided into four groups of 10: control,exercise,Alzheimer's,and exercise+Alzheimer's.The exercise protocol included 2 weeks of running on a treadmill at a speed of12 m/min and for 30minutes in each session. At the end of the training period, feeding sensation suppression and tail suspension tests were performed to estimate depression as well as hippocampal and prefrontal malondialdehyde levels using the Bradford method.
Results:The results showed that exercise training significantly reduced the rate of depression in Novelty-suppressed feeding test and suspension test in rats with Alzheimer's disease.Also,exercise training significantly reduced malondialdehyde levels in the hippocampus of rats with Alzheimer's disease while no significant difference was observed in the prefrontal.
Discussion It seems that sports activity can create immunity against Alzheimer's disease and is probably effective in preventing the occurrence of depression in Alzheimer's patients.
Mr Reza Asadi, Dr Mohammad Reza Kordi, Dr Fatemeh Shabkhiz,
Volume 21, Issue 25 (9-2023)
Abstract
Neurodegenerative processes play an important role in the progression of MS. Appropriate exercise training and living in an enriched environment (EE) can improve or prevent the progression of the disease through the secretion of some neurodevelopmental factors in the hippocampus, including irisin and the neutrophic factor derived from the mouse. The aim of the present study was to investigate the effect of 4 weeks of aerobic and resistance training and EE on irisin protein and hippocampus BDNF levels in female C57BL6 mice with experimental autoimmune encephalomyelitis (EAE). 50 female mice (age 8 weeks, average weight 18 ± 2 grams) were randomly divided into five equal groups (10 mice in each group): 1- healthy control, 2- control + EAE, 3- resistance activity + EAE, 4- Aerobic activity + EAE and 5- EE + EAE. The first and second weeks of adaptation to the environment and then induction of EAE were performed. The training groups trained 5 days a week for half an hour a day for 4 weeks, and the EE group was transferred to its equipped cage. 48 hours after the last training session, the mice were anesthetized and then dissected and tissue removed. The ELISA method was used to measure the amounts of proteins, and the analysis of variance and Tukey's t-test were used to determine the differences between the research variables. All analyzes were performed at a significance level of 0.05 and with SPSS22 software. Hippocampal BDNF expression was increased in all three training groups compared to the EAE control group. This increase in the EE and resistance training group was significant compared to both the EAE control group and the swimming training group. Also, hippocampal irisin expression increased in all three training groups compared to the EAE control group, and this increase was significant in the EE and resistance training groups. Also, the expression of irisin in the EE group increased more than the two aerobic swimming and resistance training groups, and this increase was proportional to It was meaningful to the swimming aerobic training group. It seems that EE and resistance training can increase the secretion of nerve growth factors such as irisin and BDNF and thus help to improve MS disease.
