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Mohammad Azimnezhad, Pezhman Motamedi, Mohammadreza Dehkhoda, Neda Khaledi,
Volume 20, Issue 23 (9-2022)

Apoptosis is a programmed cell death and it’s associated with type 2 diabetes. The aim of present study was to investigate the effect of endurance training on caspase-3, Bcl-2 and Bax gene expression of cardiac tissue in type 2 diabetic male wistar rats.In an experimental trial, 36 male wistar rats were randomly divided into three groups, Diabetic Endurance Training (n=12), Diabetic Control (n=12) and Healthy Control (n=12). Type 2 diabetes was induced by intraperitoneal injection of STZ. The endurance training included 10 weeks, 5 sessions per week running at speed of 27 m/min for 20-30min in 1st week and reached to 27 m/min for 60 min/day in 10th weeks. The animals were sacrificed 24 h after last training session and the samples were taken from cardiac tissue. The gene expression of caspase-3, Bcl-2 and Bax were examined by Real time-PCR. The one-way ANOVA was used to analysis the data. The significant level was set at p<0.05. The gene expression of caspase-3and Bax of diabetic control group showed significant increase comparing with healthy control group (p =0.001) while gene expression of Bcl-2 significantly decreased (p =0.001). The endurance training induced significant reduction in the gene expression of caspase-3and Bax (p =0.001) and significant increase in the Bcl-2 compared to diabetic control group (p =0.001). It appears that gene expression of caspase-3, Bcl-2 and Bax of diabetic cardiac tissue are affected by positive effect of endurance training and the endurance training induces improvement in apoptosis of diabetic cardiac tissue.

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