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The effect of continuous aerobic training in improving sarcopenia, changes in myofibrils and sports performance in elderly rats with Alzheimer's disease
Ssaeedeh Shiri Lord, Roghayeh Fakhrpour, Karim Azali Alamdari,
Volume 0, Issue 0 (11-2019)
Abstract
Background and Purpose; Sarcopenia is a progressive and generalized skeletal muscle disorder that involves rapid loss of muscle mass and function. The purpose of this study was to investigate the effect of continuous aerobic exercise on sarcopenia, changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's disease, to investigate the effect of physical activity on reducing sarcopenia and changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's  should be measured.
Materials and Methods; In the present study, 40 aged Wistar rats with an average weight of 300 grams. The rats were randomly divided into four ten groups including control patient, training patient, healthy control, healthy training. The exercise group participated in a six-week continuous aerobic exercise program. The patient group was diagnosed with Alzheimer's disease by intraperitoneal injection of scopolamine for 14 days, and after ensuring the induction of Alzheimer's disease using the novel object recognition test, the training group participated in a six-week continuous aerobic training program.
Results; Based on the results after six weeks of continuous aerobic training, according to the measurement of the tissue components in the soleus and EDL muscles of the healthy group of rats under training, it showed a slight increase in the extent of the tissue parenchyma and the diameter of the muscle fibers compared to the healthy control group, but these changes were not significant. The quantification of the extent of the tissue components in the soleus and EDL muscles of the studied rats showed a significant decrease in the muscle parenchyma and also a significant decrease in the average diameter of the muscle fibers in the patient group compared to the healthy control group (p<0.01). The area of the muscle parenchyma and the average diameter of the soleus and EDL muscle fibers in the mice of the patient group under training compared to the mice of the patient group showed a significant increase in tissue (p<0.05) and the amount of tissue edema and the presence of connective tissue showed a significant decrease (p<0.01 and p<0.05).
Conclusion: According to the findings, it seems that sports activities have positive effects on sarcopenia disease and myofibril changes, as well as the sports performance of rats with Alzheimer's disease.
Keywords: continuous aerobic exercises, Alzheimer's, sarcopenia, muscle myofibril
Background and Purpose; Sarcopenia is a progressive and generalized skeletal muscle disorder that involves rapid loss of muscle mass and function. The purpose of this study was to investigate the effect of continuous aerobic exercise on sarcopenia, changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's disease, to investigate the effect of physical activity on reducing sarcopenia and changes in myofibrils in skeletal muscle and exercise performance in elderly rats with Alzheimer's  should be measured.
Materials and Methods; In the present study, 40 aged Wistar rats with an average weight of 300 grams. The rats were randomly divided into four ten groups including control patient, training patient, healthy control, healthy training. The exercise group participated in a six-week continuous aerobic exercise program. The patient group was diagnosed with Alzheimer's disease by intraperitoneal injection of scopolamine for 14 days, and after ensuring the induction of Alzheimer's disease using the novel object recognition test, the training group participated in a six-week continuous aerobic training program.
Results; Based on the results after six weeks of continuous aerobic training, according to the measurement of the tissue components in the soleus and EDL muscles of the healthy group of rats under training, it showed a slight increase in the extent of the tissue parenchyma and the diameter of the muscle fibers compared to the healthy control group, but these changes were not significant. The quantification of the extent of the tissue components in the soleus and EDL muscles of the studied rats showed a significant decrease in the muscle parenchyma and also a significant decrease in the average diameter of the muscle fibers in the patient group compared to the healthy control group (p<0.01). The area of the muscle parenchyma and the average diameter of the soleus and EDL muscle fibers in the mice of the patient group under training compared to the mice of the patient group showed a significant increase in tissue (p<0.05) and the amount of tissue edema and the presence of connective tissue showed a significant decrease (p<0.01 and p<0.05).
Conclusion: According to the findings, it seems that sports activities have positive effects on sarcopenia disease and myofibril changes, as well as the sports performance of rats with Alzheimer's disease.


 
The Effect Of A Period Of Aerobic Exercises On Of Depression And Changes The Oxidative Stress In The Hippocampus And Prefrontal
Azam Davoodabadi, Saeed Naqeibi, Ali Barzegari, Mohammad Hassaan Dashty Khavidaki,
Volume 22, Issue 27 (8-2024)
Abstract
The aim of this study was the effect of a course of aerobic exercises on depression and oxidative stress factor changes in the hippocampus and prefrontal cortex of rats with Alzheimer's disease. For this purpose, 40 8-week-old male Wistar rats with an average weight of 237±33 grams were randomly divided into four groups of 10: control, exercise, Alzheimer's, and exercise+Alzheimer's. The training protocol consisted of 12 weeks of running on a treadmill at a speed of 12 meters per minute and for 30 minutes in each session. At the end of the training period, the tests of feeding sensation suppression and tail suspension were performed to estimate depression as well as hippocampal and prefrontal malondialdehyde levels using the Bradford method. Also, in order to induce Alzheimer's, an amount of three mg/kg of streptozocin in a volume of five microliters of sterile distilled water was injected into the ventricle of the brain. The results showed that exercise training caused a significant decrease in depression in eating delay tests and immobility duration in Alzheimer's rats. Also, exercise caused a significant decrease in malondialdehyde levels in the hippocampus of Alzheimer's rats, while a significant difference was observed in the prefrontal area. It didn't happen. It seems that sports activity creates immunity against Alzheimer's and is probably effective in preventing depression in Alzheimer's patients.

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