Dr Sara Zare Karizak, Mis Zaynab Teimouri, Dr Abdosaleh Zar,
Volume 0, Issue 0 (11-2019)
Abstract
Introduction
High-Intensity exercise is accompanied by inflammation and oxidative stress. This study aimed to investigate the effect of the FIFA test with curcumin supplementation on serum MDA, TAC, and CRP in male football assistant referees.
Method
In this semi-experimental study, 20 football assistant referees (mean age 28.56±3.75 years, height 179±4.21 cm, weight 72.78±7.08 kg) were selected voluntarily then were randomly assigned to the curcumin + FIFA test and the FIFA test groups. The test + supplement group, in addition to FIFA tests, received 5 grams of curcumin daily (2.5gram at morning and 2.5 gram at evening) for five days. Blood sampling was performed in three stages (before supplementation, two and a half day before, immediately after, and 48 hours after the FIFA Interval Physical Fitness Test) and serum levels of variables were measured using the spectrophotometric method. Repeated-measures ANOVA and Bonferoni post hoc tests were performed in SPSS26.
Results
There was significant increase in serum CRP, MDA, and TCA in both groups in the first post-test (P=0.000, P=0.041, P=0.008, P=0.009, P= 0.048, P=0.014). Also, in the second post-test of the test group, the increase in CRP and MDA levels remained significant (P = 0.000, P = 0.022). However, TAC became a non-significant increase (P=0.160), while its increase in the test + supplement group was still significant (P=0.013), and in the test + supplement group, MDA became a non-significant increase compared to the pre-test (P=0.186), while in the test group it still had a significant increase (P=0.022). In addition, there was a significant difference between the groups in CRP and TAC values (P=0.024, P=0.05) and a non-significant difference in MDA levels (P=0.129).
Conclusion
Curcumin modulates some of the inflammatory and oxidative stress indices induced by endurance exercise (the FIFA test).
Fadideh Alabaf Yousefi, Roghayeh Pouzesh Jadidi, Jabbar Bashiri, , Javad Vakili,
Volume 19, Issue 22 (12-2021)
Abstract
Background and Objective: the aim was to investigate the effects of 12 weeks of High Intensity Interval Training (HIIT) and curcumin supplementation on expression levels of FSTL1 and Smad7 and also Type I, III and IV collagens in rat model with myocardial infraction (MI). Methodology: 48 male rats were randomized into five groups of Reference, HIIT, Curcumin, Concomitant (HIIT+ Curcumin) and Control, following isoproterenol induced myocardial infarction. After Reference group execution in order to conform the MI, curcumin was administrated through oral gavage 15 mg/kg.day. HIIT sessions were conducted for five days per week, each session for 60 minutes, consisted of 10 bouts (each for 4 min) of running repetitions at 85-90% of v VO2 peak separated by 2 min active rest intervals between running periods. Left ventricular FSTL1, Smad7 and also type I, III and IV collagens expression level was detected by western blotting. Results: In all three intervention groups of HIIT, Curcumin and Concomitant, the cardiac weight was significantly higher (p=0.001, p=0.018 and p=0.001 respectively), while type IV collagen expression level was significantly lower (p=0.001 in any circumstances) than Control group. However, only in the Concomitant group, a significantly lower type III collagen (p=0.033) expression level as well as higher FSTL1 (P=0.001) and Smad7 (P=0.008) expressions were recorded, compared to the Control group. Conclusion: A diminished cardiac type IV collagen expression level in accompany with a zero mortality rate in all three interventions could likely imply on the safety of HIIT as well as curcumin supplementation to suppress post infraction myocardial fibrosis. However, only concomitant intervention could decrease infracted left ventricular type III collagen expression level, with an elevated FSTL1 and Smad7 expressions, which outlines their synergistic prescription to achieve better results. However, more researches remains to be done because of the lack of evidence and study limitations.
