E Fasihi Ramandi, N Khaledi,
Volume 18, Issue 19 (7-2020)
Abstract
Diabetes is a common metabolic disease. In diabetic patients glucose uptake is reduced and FGF-21 plays an important role in glucose uptake, alsoTNF-α is an inflammatory factor that increases in diabetes. The purpose of this study was to investigate the effect of 6 weeks of HIIT training on the gene expression FGF-21 in the liver and the serum TNF-α level of male diabetic rats. For this purpose, 48 Wistar rats were randomly divided into four groups Control, diabetes, high intensity interval training, and diabetes and high intensity interval training. For the induction of diabetes, peritoneal injection (Streptozotocin 50 mg/kg) was used. Training protocol including 10 set of 1-minute running (between each set of 2 minutes of rest) 3 sessions per week and was completed within 6 weeks. Finally, after the extraction of liver samples, the expression of the FGF-21 gene was measured by Real Time PCR and serum TNF-α level with ELISA kit.There was no significant change in expression of FGF-21 in any group, but the reduction of serum levels of inflammatory factors, such as TNF-α protein at the level of significance (p=0.05), and maintaining and improving the time to exhaustion, was shown by high intensity interval training (0.000).Likely the inflammatory factors of diabetes such as TNF-α have a deleterious effect on the expression and binding of FGF-21 (β-Klotho) cofactors And causes resistance to FGF-21 into various tissues of the body, such as the liver. Exercise can reduce inflammation caused by diabetes.
Dr Ali Asghar Ravasi, Dr Mousa Khalafi, Dr Karim Azali Alamdari,
Volume 19, Issue 22 (12-2021)
Abstract
Background and objective: Effects of exercise training on metabolic disorders through modifications in fibroblast growth factor -21 (FGF-21) level are controversial. Therefore, the aim of study was to determine the quantitative effect of exercise training protocols on serum FGF-21 level in adults with metabolic disorders. Methods: A systematic search of the published Persian or English-language studies from PubMed and Google Scholar databases up to march 2021 was done and standardized mean differences (SMDs) were calculated using random-effects models. Results: a total of 14 studies (aerobic training=3, resistance training=3, HIIT=4, concurrent training=4) including on 19 interventions conducted on 503 subjects (with overweight, obesity, type 2 diabetes, metabolic syndrome and or fatty liver disease) were eligible to include in the meta-analysis. However, because of the heterogeneity, the final quantitative impact of 16 interventions was calculated as a declining serum FGF21 level after training [SMD=-0.44(CI: -0.65 to -0.22) p=0.001] which had no correlation with subjects age(p=0.10) or BMI(p=0.50) level. Conclusion: exercise training protocols are efficient tools for a remarkable decrease in serum FGF-21 in patients with metabolic disorders which seems to lead to more beneficial effects on metabolic disturbances. However, more clinical trials are still warranted in this area considering the role of exercise components such as exercise intensity and type
