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Showing 4 results for Insulin Resistance

Dr Rohollh Nikooie, Msr Bahareh Hajmalek, Dr Dariush Moflehi, Mr Amir Nejad Vaziri,
Volume 0, Issue 0 (11-2019)
Abstract

Background: This semi-experimental study aimed to investigate the effect of insulin resistance on substrate selection during exercise in obese diabetic women.
Methods: 24 inactive obese women, including control (C; n=8,BMI=31.03±1.18), non-insulin resistance (NIR;n=8,BMI=30.91±0.78), and insulin resistance (IR, n=8,BMI=31.57±0.91) groups, were purposely selected and performed a standard incremental test with an initial workload of 50 W and increased in the workload of 20 W every three minutes. Respiratory gases were collected throughout the test. Cross-over point (COP), a point at which the metabolic substrate changes from fat to carbohydrates, and FATmax point at which fat has the highest contribution to energy supply, were determined. Heart rate and oxygen consumption corresponding to COP and FATmax, points were calculated and compared among the groups using one-way analysis of variance (ANOVA).
Results: In both diabetic groups, heart rate (P<0.001) and oxygen consumption (P<0.001) corresponding to COP were significantly lower compared to the C. Both variables had lower values in the IR compared to the NIR (P<0.001). In both diabetic groups, oxygen consumption corresponding to the FATmax point was significantly lower compared to the C (P<0.001) and had lower values in IR compared to the NIR (P<0.001). Conclusion: In general, the results of the present study showed that insulin resistance is associated with more reliance on carbohydrates and diminished fat oxidation at submaximal exercise intensities.
 
, ,
Volume 11, Issue 5 (3-2013)
Abstract

improves insulin resistance. However, the effect of training sessions a day is not
clear in this regard. The aim of this study was to investigate the effect of one or
two sessions a day of exercise training, with equal intensity and duration, on
insulin resistance in sedentary middle-aged men. Materials & Methods: 30
sedentary middle-aged male volunteers (age=43.6±6.5 yr, weight=80.4±13.6kg,
height=174.1±5.5cm,BMI=26.5±3.6kg/m2،VO2max=35.46±6ml/kg) randomized to
the control (n=10), one session a day (n=10)and two sessions a day training
group( n=10). Exercise program consisted of 16 weeks, five days a week, tread
mill running which was implemented as one (30 minutes) or two sessions (2×15
minutes) a day. Training intensity was 40-50% of HRmax at first week and
reached to 70-80% at 16th week of the training. Measurements of fasting blood
samples (insulin, glucose and adiponectin), insulin resistance, cardiorespiratory
fitness, abdominal obesity and BMI were obtained at baseline and post
exercise. Paired t test and analysis of Variance were used to analyze the data.
Results: After 16 weeks of training, compared with the control group, a
significant reduction in blood glucose, abdominal obesity and BMI, and a
significant increase in cardiorespiratory fitness were observed in the both
experimental groups; whereas insulin resistance remained unchanged, and
adiponectin was significantly increased only in the one session a day training
group. Conclusion: based on the findings it seems that, dividing the physical
activity session in two shorter parts can improve glucose profile, cardiorespiratory
fitness and obesity indicators the same as a continuous exercise session. But in
terms of increased adiponectin and decreased abdominal obesity, continuous
exercise session is more effective.


Mrs Sahar Khademi, Dr Roohallah Ranjbar, Dr Mohsen Ghanbarzadeh,
Volume 13, Issue 10 (10-2015)
Abstract

The purpose of this study was the effect of eight weeks of circuit training on the Irisin levels and
the Insulin Resistance Index (HOMA-IR) in overweight women. Materials and Methods: In this study 22
overweight women voluntarily were chosen (Age 26.04±4.43 yrs, BMI 29.35±2.53 kg/m2) and were divided
to two groups of control (n=11) and experimental (n=11). In the experimental group, subjects performed
circuit training for eight weeks and four times per week. Blood sample was taken before and 48 hours after
the last training session. Statistical analysis at the level of P<0.05 was done. Findings: After eight weeks of
training, the level of Irisin in experimental group significantly increased while the HOMA-IR had a
significant reduction (p<0.05). Also Pearson correlation co-efficiency test shows that there is a reverse
relationship between irisin and HOMA-IR (P≤0.05). Conclusion: It appears that circuit training improves
body composition and metabolic disorders such as insulin resistance through Irisin induction in overweight
women.


Dr Ramin Amir Sasan, Dr Kamal Aziz Beigi, Dr Bahman Mirzaei, Mrs Khorshid Parsafar,
Volume 14, Issue 11 (4-2016)
Abstract

Homocysteine and insulin resistance in postmenoupausal women rises due to decrease in estrogen, low mobility and weight gain which increase the cardiovascular diseases. The aim of this study was to examine the effects of aerobic exercise training status on response of homocysteine and insulin resistance to aerobic exercise in active and nonactive obese postmenopausal women. Therefore, 21 obese postmenopausal women with the age of 48 - 65 yrs voluntary participated in the study and assigned in active (n=11) and nonactive (n=10) groups. Aerobic exercise was performed with 70-75 percent of maximum heart rate. Blood sample was obtained before and after exercise, and 10 hours following fasting. Results showed that baseline levels of ​​homocysteine (p= 0.003) ​​and insulin resistance (p=0.003) were significantly lower in active subjects compared with inactive ones. However, homocysteine level was significantly (p=0.028) lower in active than to nonactive subjects following aerobic exercise. It can be concluded that regular aerobic training improves insulin resistance and homocysteine levels in obese postmenopausal women, however, a session of moderate aerobic exercise could not influence on insulin resistance. Although, homocysteine response was higher in active group. It seems that changes manner of two variable to aerobic exercise is different



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