Khadijeh Molaei, Sanaz Mirzayan Shanjani, Ali Gorzi, Yaser Kazemzadeh, Abdolali Banaeifar,
Volume 0, Issue 0 (11-2019)
Abstract
Testosterone enanthate increases muscle growth and athletic performance but is associated with oxidative stress and tissue damage. This study aimed to investigate the effect of propolis on oxidative stress markers induced by testosterone enanthate in the kidney tissue of female Wistar rats undergoing resistance training. Twenty-two 8-week-old female rats, weighing 208.22±14.17 g, were randomly divided into three groups: 1) resistance training + placebo (n=6), 2) resistance training + testosterone enanthate (n=8), 3) resistance training + testosterone enanthate + propolis (n=8). The rats underwent an 8-week resistance training protocol involving ladder climbing (five days per week). Testosterone enanthate was administered at a dose of 20 mg/kg body weight per injection, and propolis was administered at a dose of 400 mg/kg body weight by gavage (each three times a week). The levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), and malondialdehyde (MDA) in kidney tissue were measured by spectrophotometry. One-way ANOVA and Bonferroni post hoc tests were used for statistical analysis. The results showed that testosterone enanthate significantly decreased GPX and SOD levels and increased MDA levels. Propolis consumption led to a relative reduction in these oxidative stress markers, demonstrating its potential antioxidant effects.
