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Showing 4 results for Multiple Sclerosis
The effect of personalized comprehensive rehabilitation training on some induces of physical function in women with multiple sclerosis with different levels of disability levels
Aliakbar Fazel, Laleh Bagheri, Nader Rahnema, Samira Emadi,
Volume 0, Issue 0 (11-2019)
Abstract
Background: In rehabilitation medicine using targeted and personalized approaches are proposed, so that training protocols adjustments, based on gender, age, level of disability and the rate of progress can have more favorable results. The purpose of this study was to investigate the effect of personalized comprehensive rehabilitation training on some induces of physical function in women with MS presenting different levels of disability.
Material & Methods:  In this quasi-experimental study, 92 patients admitted to the MS Society of Shahrekord city were selected and on the basis of disability were categorized into 3 groups of mild, moderate and severe. Then each group was randomly divided into experimental and control group. The personalized comprehensive rehabilitation training program was done 12 weeks, 3 times per weeks. Muscles strength, endurance and speed of walking, were assessed. Independent and Covariance test were used for data analysis.
Results: The results showed that 12 weeks training cause improving in muscles strength, speed of walking in women with MS presenting different levels of disability (p<0.05). Endurance of walking improve significantly in mild group (p<0.05), but in moderate and severe group were not significantly (P˃0.05).
Conclusion: The implementation of the comprehensive rehabilitation exercises affected the recovery of patients with MS and made a significant difference in physical functions of patients.
 
Relationship between Static and Dynamic Balance Characteristics with Types of MS in Women
B Behaeen, H Sadeghi, H Same, S Mashhudi,
Volume 9, Issue 1 (3-2011)
Abstract

MS is a lifelong disease that could involve the person in different forms. Knowing balance characteristics of different types of this chronic disease helps the specialists for controlling their complications. The purpose of this study was to recognize static and dynamic balance of different type of MS and to compare MS patients with healthy individual. 54 MS women in three groups (27- Relapsing-Remitting, 16 secondary progressive, 11 primary progressive), 20 randomly healthful women have been elected. Static and dynamic balance test (dynamics with 8 degree), overall, lateral and anterior/posterior have been done by Biodex machinery from four groups. Kolmogorov-Smirnov inferential statistic test used to assess the normality of the data distribution and the chi-square test was used to examine the relationship within and between types of MS disease with normal. The parametric statistics tests including independent t-test applied at threshold 0.05. According to results, there are meaningful difference between overall balance index in static balance in different types of diseased women affected by MS (p<0.05). The Primary Progressive groups have weak, and Relapsing-Remitting MS group have strong static balance in comparison with other groups. Furthermore, meaningful difference shown through overall balance index in static mood in different type of disease women affected by MS (p<0.05). Difference between static balance index and dynamic was meaningful between control group and MS disease. Considering the findings of the study, women affected by relapsing-remitting type have better dynamic & static balance rather than progressive types. Static & dynamic balance in affected women was weaker than healthy women.


The effect of comprehensive sports rehabilitation protocol on resting levels of Neurotrophin-4/5 (NT-4/5), anthropometric and functional variables in patients with multiple sclerosis with different levels of disability
Abdolreza Kazemi, Fatemeh Khajepor, Alireza Sharifabadi, Mahdi Madahi,
Volume 18, Issue 20 (11-2020)
Abstract
Due to the positive affect of the training on the improvement of MS, "the effect of the comprehensive training on neurotrophin- 4/5 and other variables in women with MS" was investigated. Experimental groups (A, B, and C) performed their intervention. Based on the level of disability, different training was used. Control groups (A, B, and C) received only stretch training. At first, all pre-tests were performed and then the experimental groups performed their exercises during 12 weeks. At the end, depended variables were measured and ANCOVA was used. According to the results, showed that rehabilitation protocol has no effect on the levels of neurotrophin 4/5 in MS patients at levels A and C (P=0.504 and P=0.083) but significant increase observed in B level (P=0.010). The results also showed that at level A: BMI, fat percentage, speed and VO2max, and at level B: weight, BMI, fat percentage, endurance, dynamic balance, waist circumference, hip circumference, WHR and VO2max had a significant improvement. On the other hand, at level C, only BMI, fat percentage and VO2max were significantly improved. These results show that rehabilitation exercises have a positive effect on these variables and can increase the quality of life in these patients.

The Effect of Enriched Environment and Two Types of Forced Exercise on Irisin and BDNF Protein Levels in the Hippocampus of Female Mice with Experimental MS
Mr Reza Asadi, Dr Mohammad Reza Kordi, Dr Fatemeh Shabkhiz,
Volume 21, Issue 25 (9-2023)
Abstract
Neurodegenerative processes play an important role in the progression of MS. Appropriate exercise training and living in an enriched environment (EE) can improve or prevent the progression of the disease through the secretion of some neurodevelopmental factors in the hippocampus, including irisin and the neutrophic factor derived from the mouse. The aim of the present study was to investigate the effect of 4 weeks of aerobic and resistance training and EE on irisin protein and hippocampus BDNF levels in female C57BL6 mice with experimental autoimmune encephalomyelitis (EAE). 50 female mice (age 8 weeks, average weight 18 ± 2 grams) were randomly divided into five equal groups (10 mice in each group): 1- healthy control, 2- control + EAE, 3- resistance activity + EAE, 4- Aerobic activity + EAE and 5- EE + EAE. The first and second weeks of adaptation to the environment and then induction of EAE were performed. The training groups trained 5 days a week for half an hour a day for 4 weeks, and the EE group was transferred to its equipped cage. 48 hours after the last training session, the mice were anesthetized and then dissected and tissue removed. The ELISA method was used to measure the amounts of proteins, and the analysis of variance and Tukey's t-test were used to determine the differences between the research variables. All analyzes were performed at a significance level of 0.05 and with SPSS22 software. Hippocampal BDNF expression was increased in all three training groups compared to the EAE control group. This increase in the EE and resistance training group was significant compared to both the EAE control group and the swimming training group. Also, hippocampal irisin expression increased in all three training groups compared to the EAE control group, and this increase was significant in the EE and resistance training groups. Also, the expression of irisin in the EE group increased more than the two aerobic swimming and resistance training groups, and this increase was proportional to It was meaningful to the swimming aerobic training group. It seems that EE and resistance training can increase the secretion of nerve growth factors such as irisin and BDNF and thus help to improve MS disease.

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