The study attempts to evaluate the effects of silver nanoparticles on preventing the destruction of ovarian tissue in mice treated with isoniazid. In this experiment, 40 adult female rats were randomly divided into 5 groups (n=8) including: control group (no treatment), sham group (0.2 mg / kg normal saline), experimental group 1 (50mg / kg Ison-iazid), experimental group 2 (50mg / kg Isoniazid and 0.25mg/kg silver nanoparticles) and the experimental group 3 (50mg / kg isoniazid and 0.50mg / kg silver nanoparticles). All injections were prescribed for 15 days and Isoniazid and silver nano-particles were received orally and intraperitoneally, respectively. All the animals were operated on and their ovarian tissues were removed and placed in 10% formalin solution. Then H & E staining was performed for histological studies. In experimental groups 1, 2 and 3, reduction in the number of secondary follicles and corpus luteum was obse-rved in comparison with the control group. There was a significant increase in the number of primordial and graafian follicles in experimental group 3 when it was compared with isoniazid group. In addition, a significant increase was observed in the number of primary monolayer follicles in experimental groups 2 and 3 in comparison with the experi-mental group 1. It should be assumed that by the utilization of the minimum dose of the silver nanoparticles, its toxic effects on the ovarian tissue could be ignored. Therefore, the minimum dose of the silver nanoparticles can reduce the isoniazid effects on ovarian tissue.