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Purpose:The aim of this study was to effect of quercetin exercise and supplementation on myostatin and folistatin levels in the heart tissue of diabetic rats.Methods:For this purpose, 50 male Wistar rats with an average weight of 237 33 33 g were randomly divided into five groups of 10 including: healthy control, diabetes, diabetes + supplement, diabetes + exercise and diabetes + supplement + exercise.The training week was five sessions per week and 60 minutes per session, and the supplement groups received 50 mg / kg body weight of quercetin daily by gavage. Located.Results:The results showed that there was a significant difference in myostatin levels between exercise + supplement and diabetes groups(P = 0.004) and myostatin levels between exercise + supplement + diabetes and diabetes groups were also significantly different (P = 0.002).There was a significant difference between the supplement + diabetes group compared to the diabetes and control groups(P = 0.001).There was also a significant difference between the supplement + diabetes and exercise + diabetes groups (P = 0.009). Rat heart tissue was observed in exercise + supplement + diabetes group compared to diabetes, control and exercise + diabetes groups(P = 0.001).Conclusion:It seems that the decrease in myocardial myostatin along with the increase in fulostatin, in addition to better showing the opposite role of these two important cardiac cardiacs in diabetic patients, also explains the importance of exercise and quercetin consumption in this disease.
Type of Study: Research | Subject: sport physiology
Received: 2022/04/14 | Accepted: 2023/05/29

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