Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

Tayanloo, Akram; Zare1, Samad; Karimzadeh-Bardei, Latifeh; Hoseini, Serwa

doi:10.21859/acadpub.nbr.4.2.181

Volume 4, Issue 2 (9-2017) nbr 2017, 4(2): 181-188 | Back to browse issues page

‎ 10.21859/acadpub.nbr.4.2.181

‎ 20.1001.1.24236330.1396.4.2.10.3

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Tayanloo A, Zare1 S, Karimzadeh-Bardei L, Hoseini S. Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate. nbr 2017; 4 (2) :181-188
URL: http://nbr.khu.ac.ir/article-1-2953-en.html

Effect of Urtica dioica hydroalcoholic extract on liver inflammatory factors in polycystic ovarian syndrome induced in Wistar rats by estradiol valerate

Akram Tayanloo ^*

, Samad Zare1

, Latifeh Karimzadeh-Bardei

, Serwa Hoseini

Urmia University

Abstract: (6904 Views)

The polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women at childbearing age. Metabolic syndrome is present from 28% to 46% of patients with PCOS. Non-alcoholic fatty liver di-sease (NAFLD) is considered the hepatic expression of metabolic syndrome. In this study Urtica dioica moderator ef-fect on liver function in PCOS rats was examined. 120 adult female Wistar rats were divided into control, PCOS and nettle-treated groups. The PCOS group was injected subcutaneously 2 mg/kg estradiol valerate. After confirmed poly-cystic in ovaries, the experimental group was injected of the nettle extract doses (150,250, 450 mg/kg BW). Then rats were killed and blood samples were evaluated. Data were analyzed using ANOVA one-way and p<0.05 was considered statistically significant. ELISA test showed a decrease in IL-6 level and CRP levels reduced in PCOS rats were treated with various concentrations of nettle. Our results show that nettle due to its antioxidant properties reduce the levels of IL-6 and CRP in nettle extract treated-PCOS compared to the PCOS.

Keywords: fatty liver, inflammation, ovary, ELISA

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