The aim of this study was the effectiveness of compassion-based therapy on reducing rumination, distress tolerance and sense of coherence in patients with MS. The design of this study was applied in terms of purpose and also a quasi-experimental pretest-posttest design with a control group in terms of implementation. The statistical population of the study included all female patients referred to the Tehran MS Association in 2020. According to the inclusion and exclusion criteria and after the initial screening (completion of pre-test questionnaires), 30 female patients were selected through available sampling and randomly assigned to two 15-individual experimental and control groups. Data collection tools included Nima Ghorbani Rumination Scale (RRS) Questionnaire, Simmons and Gaher Distress Tolerance Scale (DTS) Questionnaire and Antonovski Sense of Coherence (SOC). Data analysis was conducted using multivariate covariance analysis and SPSS 25 software. The results indicated that there is a significant difference in a specific level (P <0.001) between the experimental and control groups in terms of rumination, distress tolerance and sense of coherence. Compassion-based therapy is one of the therapies in the field of third wave psychology that reduces rumination and increases the distress tolerance and sense of coherence in patients with MS.
