The aim of this study was to investigate the structural relationship among Behavioural inhibition system (BIS) and Behavioural activation system (BAS), dispositional mindfulness and alexithymia. For this reason, in a descriptive-coorelational and retrospective study, 180 university students were selected from Tabriz University by convenient sampling method and asked to answer TAS-20, FFMQ and BIS/BAS scale. Results showed that behavioural inhibition system has sinificantly positive and direct effect on dispositional mindfulness and alexithymia. There is not significant relationship between dispositional mindfulness and alexithymia. The indirect effect of behavioural inhibition system and behavioural activation system on alexithymia is not significant. According to the results, the behavioural inhibition system is the important determinants of mindfulness and alexithymia. Also, the tested model able to explain alexithymia in normal people.