Volume 9, Issue 4 (volume9, Issue 4 2022)                   JCP 2022, 9(4): 35-53 | Back to browse issues page

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Hallajian A, Dehghani-Arani F, Rostami R, Bayat M ‌, Rahmati Y. The role of temporo-parietal junction on implicit mentalizing in autism spectrum disorder: a theta-burst stimulation study. JCP 2022; 9 (4) : 50
URL: http://jcp.khu.ac.ir/article-1-3483-en.html
University of Tehran , f.dehghani.a@ut.ac.ir
Abstract:   (3889 Views)
The temporo-parietal junction is a key region in the theory of mind process. Numerous brain imaging studies have demonstrated its involvement in the mentalizing process and its under-activation in autism. This study aimed to investigate the causal relationship between rTPJ activation and implicit mentalizing in autism spectrum disorder. This study is a single-blind Quasi-experimental study with a repetitive measures design. Nine children and adolescents with autism were recruited by convenience sampling method using Gilliam autism rating scale (GARS), Social Responsiveness Scale (SRS), and Stanford-Binet (SB). Afterward, they were assigned to three randomly ordered stimulation sessions: cTBS, iTBS, and sham. Immediately after each session indexes related to the subject’s implicit mentalizing were measured by a computer-based task. Repeated-measures ANOVA results demonstrated that the active stimulation sessions improved implicit mentalizing compared to sham sessions. It seems that there is a causal relation between rTPJ activation and implicit mentalizing.
Article number: 50
Full-Text [PDF 1588 kb]   (703 Downloads)    
Type of Study: Research | Subject: Psychology - Clinical Neuropsychology
Received: 2021/09/11 | Accepted: 2022/02/2 | Published: 2022/02/6

1. Apperly, I. A., & Butterfill, S. A. (2009). Do Humans Have Two Systems to Track Beliefs and Belief-Like States? Psychological Review, 116(4), 953-970. [DOI:10.1037/a0016923]
2. Bardi, L., Desmet, C., & Brass, M. (2019). Spontaneous Theory of Mind is reduced for nonhuman-like agents as compared to human-like agents. Psychological Research, 83(7), 1571-1580. [DOI:10.1007/s00426-018-1000-0]
3. Bardi, L., Desmet, C., Nijhof, A., Wiersema, J. R., & Brass, M. (2017). Brain activation for spontaneous and explicit false belief tasks overlaps: New fMRI evidence on belief processing and violation of expectation. Social Cognitive and Affective Neuroscience. [DOI:10.1093/scan/nsw143]
4. Baron-Cohen, S. (1989). The Autistic Child's Theory of Mind: a Case of Specific Developmental Delay. Journal of Child Psychology and Psychiatry, 30(2), 285-297. [DOI:10.1111/j.1469-7610.1989.tb00241.x]
5. Bergmann, T. O., & Hartwigsen, G. (2020). Inferring causality from noninvasive brain stimulation in cognitive neuroscience. Journal of Cognitive Neuroscience, 33(2). [DOI:10.1162/jocn_a_01591]
6. Beynel, L., Appelbaum, L. G., Luber, B., Crowell, C. A., Hilbig, S. A., Lim, W., … Deng, Z.-D. (2019). Effects of online repetitive transcranial magnetic stimulation (rTMS) on cognitive processing: A meta-analysis and recommendations for future studies. Neuroscience & Biobehavioral Reviews, 107, 47-58. https://doi.org/10.1016/j.neubiorev.2019.08.018 [DOI:https://doi.org/10.1016/j.neubiorev.2019.08.018]
7. Boccadoro, S., Cracco, E., Hudson, A. R., Bardi, L., Nijhof, A. D., Wiersema, J. R., … Mueller, S. C. (2019). Defining the neural correlates of spontaneous theory of mind (ToM): An fMRI multi-study investigation. NeuroImage, 203(March), 116193. [DOI:10.1016/j.neuroimage.2019.116193]
8. Bowler, D. M. (1992). "Theory of Mind" in Asperger's Syndrome Dermot M. Bowler. Journal of Child Psychology and Psychiatry. [DOI:10.1111/j.1469-7610.1992.tb01962.x]
9. Brass, M., Ruby, P., & Spengler, S. (2009). Inhibition of imitative behaviour and social cognition. Philosophical Transactions of the Royal Society B: Biological Sciences, 364(1528), 2359-2367. [DOI:10.1098/rstb.2009.0066]
10. Bukowski, H., Tik, M., Silani, G., Ruff, C. C., Windischberger, C., & Lamm, C. (2020). When differences matter: rTMS/fMRI reveals how differences in dispositional empathy translate to distinct neural underpinnings of self-other distinction in empathy. Cortex, 128, 143-161. [DOI:10.1016/j.cortex.2020.03.009]
11. Callenmark, B., Kjellin, L., Rönnqvist, L., & Bölte, S. (2014). Explicit versus implicit social cognition testing in autism spectrum disorder. Autism, 18(6), 684-693. [DOI:10.1177/1362361313492393]
12. Carruthers, P. (2017). Mindreading in adults: evaluating two-systems views. Synthese, 194(3), 673-688. [DOI:10.1007/s11229-015-0792-3]
13. Chung, S. W., Hill, A. T., Rogasch, N. C., Hoy, K. E., & Fitzgerald, P. B. (2016). Use of theta-burst stimulation in changing excitability of motor cortex: A systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 63, 43-64. [DOI:10.1016/j.neubiorev.2016.01.008]
14. Cieza, A., Causey, K., Kamenov, K., Hanson, S. W., Chatterji, S., & Vos, T. (2020). Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet, 396(10267), 2006-2017. [DOI:10.1016/S0140-6736(20)32340-0]
15. Constantino, J. N., & Gruber, C. P. (2012). Social responsiveness scale: SRS-2. Western Psychological Services Torrance, CA.
16. Costa, A., Torriero, S., Oliveri, M., & Caltagirone, C. (2008). Prefrontal and temporo-parietal involvement in taking others ' perspective : TMS evidence, 19, 71-74. [DOI:10.1155/2008/694632]
17. Crescentini, C., Di Bucchianico, M., Fabbro, F., & Urgesi, C. (2015). Excitatory stimulation of the right inferior parietal cortex lessens implicit religiousness/spirituality. Neuropsychologia, 70. [DOI:10.1016/j.neuropsychologia.2015.02.016]
18. Decety, J., & Lamm, C. (2007). The role of the right temporoparietal junction in social interaction: How low-level computational processes contribute to meta-cognition. Neuroscientist, 13(6), 580-593. [DOI:10.1177/1073858407304654]
19. Demehri F, Khatibi T, Azizi M. Comparison of Executive Functions and Learning Strategies among Autistic Students with High and Low Academic Performance. JCP. 2020; 8 (3) :86-96
20. Der, G., & Deary, I. J. (2003). IQ, reaction time and the differentiation hypothesis. Intelligence, 31(5). [DOI:10.1016/S0160-2896(02)00189-7]
21. Deschrijver, E., Bardi, L., Wiersema, J. R., & Brass, M. (2016). Behavioral measures of implicit theory of mind in adults with high functioning autism. Cognitive Neuroscience, 7(1-4), 192-202. [DOI:10.1080/17588928.2015.1085375]
22. Di Lazzaro, V., Pilato, F., Saturno, E., Oliviero, A., Dileone, M., Mazzone, P., … Rothwell, J. C. (2005a). Theta-burst repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortex. Journal of Physiology, 565(3), 945-950. [DOI:10.1113/jphysiol.2005.087288]
23. Di Lazzaro, V., Pilato, F., Saturno, E., Oliviero, A., Dileone, M., Mazzone, P., … Rothwell, J. C. (2005b). Theta-burst repetitive transcranial magnetic stimulation suppresses specific excitatory circuits in the human motor cortex. Journal of Physiology, 565(3). [DOI:10.1113/jphysiol.2005.087288]
24. Döhnel, K., Schuwerk, T., Meinhardt, J., Sodian, B., Hajak, G., & Sommer, M. (2012). Functional activity of the right temporo-parietal junction and of the medial prefrontal cortex associated with true and false belief reasoning. NeuroImage. [DOI:10.1016/j.neuroimage.2012.01.073]
25. Eddy, C. M. (2016). Neuropsychologia The junction between self and other ? Temporo-parietal dysfunction in neuropsychiatry. Neuropsychologia, 89, 465-477. [DOI:10.1016/j.neuropsychologia.2016.07.030]
26. El Kaddouri, R., Bardi, L., De Bremaeker, D., Brass, M., & Wiersema, J. R. (2019). Measuring spontaneous mentalizing with a ball detection task: putting the attention-check hypothesis by Phillips and colleagues (2015) to the test. Psychological Research, (0123456789). [DOI:10.1007/s00426-019-01181-7]
27. Enticott, P. G., Barlow, K., Guastella, A. J., Licari, M. K., Rogasch, N. C., Middeldorp, C. M., … Fitzgerald, P. B. (2021). Repetitive transcranial magnetic stimulation (rTMS) in autism spectrum disorder: protocol for a multicentre randomised controlled clinical trial. BMJ Open, 11(7), e046830. [DOI:10.1136/bmjopen-2020-046830]
28. Frith, U., & Happé, F. (1994). Autism: beyond "theory of mind." Cognition, 50(1-3), 115-132. [DOI:10.1016/0010-0277(94)90024-8]
29. Giardina, A., Caltagirone, C., & Oliveri, M. (2015). The temporoparietal junction modulates self-Other motor representations during online and offline social motor conflict: An rTMS study. NeuroReport, 26(1), 1-5. [DOI:10.1097/WNR.0000000000000282]
30. Gilliam, J. (1995). Gilliam autism rating scale : examiner's manual. Austin TX: Pro-Ed.
31. Hamada, M., Murase, N., Hasan, A., Balaratnam, M., & Rothwell, J. C. (2013). The role of interneuron networks in driving human motor cortical plasticity. Cerebral Cortex, 23(7). [DOI:10.1093/cercor/bhs147]
32. Hill, E. L., & Frith, U. (2003). Understanding autism: insights from mind and brain. Philosophical Transactions of the Royal Society B: Biological Sciences, 358(1430), 281-289. [DOI:10.1098/rstb.2002.1209]
33. Jannati, A., Block, G., Oberman, L. M., Rotenberg, A., & Pascual-Leone, A. (2017). Interindividual variability in response to continuous theta-burst stimulation in healthy adults. Clinical Neurophysiology (Vol. 128). International Federation of Clinical Neurophysiology. [DOI:10.1016/j.clinph.2017.08.023]
34. Jannati, A., Block, G., Ryan, M. A., Kaye, H. L., Kayarian, F. B., Bashir, S., … Rotenberg, A. (2020). Continuous Theta-Burst Stimulation in Children With High-Functioning Autism Spectrum Disorder and Typically Developing Children . Frontiers in Integrative Neuroscience . Retrieved from https://www.frontiersin.org/article/10.3389/fnint.2020.00013 [DOI:10.3389/fnint.2020.00013]
35. Joshi, G., Wozniak, J., Petty, C., Martelon, M. K., Fried, R., Bolfek, A., … Biederman, J. (2013). Psychiatric comorbidity and functioning in a clinically referred population of adults with autism spectrum disorders: A comparative study. Journal of Autism and Developmental Disorders. [DOI:10.1007/s10803-012-1679-5]
36. Karalunas, S. L., Geurts, H. M., Konrad, K., Bender, S., & Nigg, J. T. (2014). Annual research review: Reaction time variability in ADHD and autism spectrum disorders: measurement and mechanisms of a proposed trans-diagnostic phenotype. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 55(6), 685-710. [DOI:10.1111/jcpp.12217]
37. Kennedy, D. P., & Courchesne, E. (2008). Functional abnormalities of the default network during self- and other-reflection in autism. Social Cognitive and Affective Neuroscience. [DOI:10.1093/scan/nsn011]
38. Kleiner, M., Brainard, D. H., Pelli, D. G., Broussard, C., Wolf, T., & Niehorster, D. (2007). What's new in Psychtoolbox-3? Perception. [DOI:10.1068/v070821]
39. Kovács, Á. M., Téglás, E., & Endress, A. D. (2010). The social sense: Susceptibility to others' beliefs in human infants and adults. Science. [DOI:10.1126/science.1190792]
40. Krall, S. C., Rottschy, C., Oberwelland, E., Bzdok, D., Fox, P. T., Eickhoff, S. B., … Konrad, K. (2015). The role of the right temporoparietal junction in attention and social interaction as revealed by ALE meta-analysis. Brain Structure and Function. [DOI:10.1007/s00429-014-0803-z]
41. Krall, Sarah C., Volz, L. J., Oberwelland, E., Grefkes, C., Fink, G. R., & Konrad, K. (2016). The right temporoparietal junction in attention and social interaction: A transcranial magnetic stimulation study. Human Brain Mapping, 37(2), 796-807. [DOI:10.1002/hbm.23068]
42. LaGasse, A. B. (2017). Social outcomes in children with autism spectrum disorder: a review of music therapy outcomes. Patient Related Outcome Measures, 8, 23-32. [DOI:10.2147/PROM.S106267]
43. Mannion, A., & Leader, G. (2013). Comorbidity in autism spectrum disorder: A literature review. Research in Autism Spectrum Disorders. [DOI:10.1016/j.rasd.2013.09.006]
44. McAllister, C. J., Rönnqvist, K. C., Stanford, I. M., Woodhall, G. L., Furlong, P. L., & Hall, S. D. (2013). Oscillatory beta activity mediates neuroplastic effects of motor cortex stimulation in humans. Journal of Neuroscience, 33(18), 7919-7927. [DOI:10.1523/JNEUROSCI.5624-12.2013]
45. Murdaugh, D. L., Nadendla, K. D., & Kana, R. K. (2014). Differential role of temporoparietal junction and medial prefrontal cortex in causal inference in autism: An independent component analysis. Neuroscience Letters. [DOI:10.1016/j.neulet.2014.03.051]
46. Murphy, C. M., Wilson, C. E., Robertson, D. M., Ecker, C., Daly, E. M., Hammond, N., … McAlonan, G. M. (2016). Autism spectrum disorder in adults: diagnosis, management, and health services development. Neuropsychiatric Disease and Treatment, 12, 1669-1686. [DOI:10.2147/NDT.S65455]
47. Nijhof, A. D., Bardi, L., Brass, M., & Wiersema, J. R. (2018). Brain activity for spontaneous and explicit mentalizing in adults with autism spectrum disorder: An fMRI study. NeuroImage: Clinical, 18(February), 475-484. [DOI:10.1016/j.nicl.2018.02.016]
48. Nijhof, A. D., Brass, M., & Wiersema, J. R. (2017). Spontaneous mentalizing in neurotypicals scoring high versus low on symptomatology of autism spectrum disorder. Psychiatry Research, 258(October), 15-20. [DOI:10.1016/j.psychres.2017.09.060]
49. Oberman, L. M., Enticott, P. G., Casanova, M. F., Rotenberg, A., Pascual-Leone, A., Mccracken, J. T., … Wall, C. (2016). Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research. Autism Research, 9(2), 184-203. [DOI:10.1002/aur.1567]
50. Oberman, L. M., Pascual-Leone, A., & Rotenberg, A. (2016). Brain Stimulation to Understand and Modulate the Autism Spectrum. Pediatric Brain Stimulation: Mapping and Modulating The Developing Brain. Elsevier Inc. [DOI:10.1016/B978-0-12-802001-2.00013-8]
51. Oberman, L. M., & Rotenberg, A. (2014). Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder, 8(August), 1-8. [DOI:10.3389/fnhum.2014.00627]
52. Oberman LM, Pascual-Leone A. Cortical plasticity: a proposed mechanism by which g nomic factors lead to the behavioral and neurological phenotype of autism spectrum and psychotic spectrum disorders. Behav Brain Sci. 2008;31:241-320. [DOI:10.1017/S0140525X08004378]
53. Obeso, I., Robles, N., Muñoz-Marrón, E., & Redolar-Ripoll, D. (2013). Dissociating the Role of the pre-SMA in Response Inhibition and Switching: A Combined Online and Offline TMS Approach . Frontiers in Human Neuroscience . Retrieved from https://www.frontiersin.org/article/10.3389/fnhum.2013.00150 [DOI:10.3389/fnhum.2013.00150]
54. Premack, D., & Woodruff, G. (1978). Does the chimpanzee have a theory of mind? Behavioral and Brain Sciences. [DOI:10.1017/S0140525X00076512]
55. Quesque, F., & Brass, M. (2019). The Role of the Temporoparietal Junction in Self-Other Distinction. Brain Topography, 1-49. [DOI:10.1007/s10548-019-00737-5]
56. Quesque, F., & Rossetti, Y. (2020). What Do Theory-of-Mind Tasks Actually Measure? Theory and Practice. Perspectives on Psychological Science, 15(2), 384-396. [DOI:10.1177/1745691619896607]
57. Salehinejad, M. A., Paknia, N., Hosseinpour, A. H., Yavari, F., Vicario, C. M., Nitsche, M. A., & Nejati, V. (2021). Contribution of the right temporoparietal junction and ventromedial prefrontal cortex to theory of mind in autism: A randomized, sham-controlled tDCS study. Autism Research, 14(8). [DOI:10.1002/aur.2538]
58. Salehinejad, M. A., Wischnewski, M., Ghanavati, E., Mosayebi-Samani, M., Kuo, M.-F., & Nitsche, M. A. (2021). Cognitive functions and underlying parameters of human brain physiology are associated with chronotype. Nature Communications, 12(1), 4672. [DOI:10.1038/s41467-021-24885-0]
59. Santiesteban, I., Banissy, M. J., Catmur, C., & Bird, G. (2012a). Enhancing social ability by stimulating right temporoparietal junction. Current Biology, 22(23), 2274-2277. [DOI:10.1016/j.cub.2012.10.018]
60. Santiesteban, I., Banissy, M. J., Catmur, C., & Bird, G. (2012b). Enhancing Social Ability by Stimulating Right Temporoparietal Junction Report Enhancing Social Ability by Stimulating Right Temporoparietal Junction. Current Biology, 22(23), 2274-2277. [DOI:10.1016/j.cub.2012.10.018]
61. Santiesteban, I., Banissy, M. J., Catmur, C., & Bird, G. (2015). Functional lateralization of temporoparietal junction - imitation inhibition, visual perspective-taking and theory of mind. European Journal of Neuroscience, 42(8), 2527-2533. [DOI:10.1111/ejn.13036]
62. Schneider, D., Slaughter, V. P., Bayliss, A. P., & Dux, P. E. (2013). A temporally sustained implicit theory of mind deficit in autism spectrum disorders. Cognition, 129(2), 410-417. [DOI:10.1016/j.cognition.2013.08.004]
63. Schurz, M., Radua, J., Aichhorn, M., Richlan, F., & Perner, J. (2014). Fractionating theory of mind: A meta-analysis of functional brain imaging studies. Neuroscience and Biobehavioral Reviews. [DOI:10.1016/j.neubiorev.2014.01.009]
64. Senju, A. (2013). Atypical development of spontaneous social cognition in autism spectrum disorders. Brain and Development, 35(2), 96-101. [DOI:10.1016/j.braindev.2012.08.002]
65. Senju, A., Southgate, V., Miura, Y., Matsui, T., Hasegawa, T., Tojo, Y., … Csibra, G. (2010). Absence of spontaneous action anticipation by false belief attribution in children with autism spectrum disorder. Development and Psychopathology, 22(2), 353-360. [DOI:10.1017/S0954579410000106]
66. Shahrivar, Z., Tehrani-Doost, M., Davoodi, E., Hosseiniani, T., Tarighatnia, H., Momen, S., … Hajirezaei, S. (2020). The reliability of the social responsiveness scale-2 in an Iranian typically developing group of children. Iranian Journal of Psychiatry, 15(1). [DOI:10.18502/ijps.v15i1.2438]
67. Sowden, S., & Catmur, C. (2015). The role of the right temporoparietal junction in the control of imitation. Cerebral Cortex, 25(4), 1107-1113. [DOI:10.1093/cercor/bht306]
68. Uddin, L. Q., Molnar-szakacs, I., Zaidel, E., & Iacoboni, M. (2006). rTMS to the right inferior parietal lobule disrupts self - other discrimination, 65-71. [DOI:10.1093/scan/nsl003]
69. Valchev, N., Tidoni, E., Hamilton, A. F. d. C., Gazzola, V., & Avenanti, A. (2017). Primary somatosensory cortex necessary for the perception of weight from other people's action: A continuous theta-burst TMS experiment. NeuroImage, 152, 195-206. [DOI:10.1016/j.neuroimage.2017.02.075]
70. Van Overwalle, F. (2009). Social cognition and the brain: A meta-analysis. Human Brain Mapping. [DOI:10.1002/hbm.20547]
71. Van Overwalle, F., & Vandekerckhove, M. (2013). Implicit and explicit social mentalizing: Dual processes driven by a shared neural network. Frontiers in Human Neuroscience. [DOI:10.3389/fnhum.2013.00560]
72. van Veluw, S. J., & Chance, S. A. (2014). Differentiating between self and others: An ALE meta-analysis of fMRI studies of self-recognition and theory of mind. Brain Imaging and Behavior. [DOI:10.1007/s11682-013-9266-8]
73. Volkmar, F. R., & Reichow, B. (2013). Autism in DSM-5: Progress and challenges. Molecular Autism. [DOI:10.1186/2040-2392-4-13]
74. White, S. J., Frith, U., Rellecke, J., Al-Noor, Z., & Gilbert, S. J. (2014). Autistic adolescents show atypical activation of the brain's mentalizing system even without a prior history of mentalizing problems. Neuropsychologia. [DOI:10.1016/j.neuropsychologia.2013.12.013]
75. Wimmer, H., & Perner, J. (1983). Beliefs about beliefs: Representation and constraining function of wrong beliefs in young children's understanding of deception. Cognition. [DOI:10.1016/0010-0277(83)90004-5]
76. Young, L., Albert, J., Hauser, M., Pascual-leone, A., & Saxe, R. (2010). Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments. [DOI:10.1073/pnas.0914826107]

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