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The present study aimed to examine the effectiveness of logotherapy on hope and post-traumatic growth in patients with colorectal cancer. This study was a quasi-experimental design with a pretest–posttest and follow-up design with a control group. The statistical population included patients with colorectal cancer referring to Imam Hossein Hospital in 2025, from which 30 participants were selected through convenience sampling and were randomly assigned to experimental and control groups (15 participants in each group). The experimental group received logotherapy intervention, while the control group received no psychological intervention. The research instruments included the Hope Scale and the Post-Traumatic Growth Inventory, and data were analyzed using repeated-measures analysis of variance in SPSS software. The results showed that logotherapy significantly increased hope and post-traumatic growth in the experimental group compared to the control group, and these effects remained relatively stable at the follow-up stage. Therefore, it can be concluded that logotherapy can be considered an effective psychological intervention for improving hope and facilitating post-traumatic growth in patients with colorectal cancer.